15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Struktur

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE

Bezeichnung:15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE

CAS-Nr2623-22-5

Englisch Name:15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE

CBNumberCB5379697

SummenformelC17H24O6

Molgewicht324.37

MOL-Datei2623-22-5.mol

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE physikalisch-chemischer Eigenschaften

Schmelzpunkt	170-172 °C
Siedepunkt	465.5±45.0 °C(Predicted)
Dichte	1.34±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	≤10mg/ml in methanol;10mg/ml in dichloromethane
Aggregatzustand	powder
pka	13.72±0.70(Predicted)
Farbe	White to off-white

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	YD0111000
HazardClass	6.1(a)
PackingGroup	II
HS Code	29329990

Gefahreninformationscode (GHS)

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Chemische Eigenschaften
Solid
Verwenden
15-Acetoxyscirpenol is a trichothecene mycotoxin and an apoptosis inducer.
Hazard
A poison by ingestion. A mild skin irritant.
Biologische Aktivität
15-acetoxy scirpenol is a trichothecene mycotoxin which is produced predominantly by members of the fusarium genus [1]. 15-acetoxy scirpenol could induce apoptotic cell death in human jurkat t cells. mycotoxins of scirpenol belong to the trichothecene family which is mainly produced by the fungal species of the genus fusarium. acetoxylated scirpenol has very high toxicities in animals and humans. 15-acetoxy scirpenol exhibited cytotoxicity at a lower concentration (25 ng/ml). the 50% inhibitory concentration (ic50) values of 15-acetoxy scirpenol was 16.1 ng/ml [2]. in the jurkat t cells treated with 50 ng/ml of 15-acetoxyscirpenol (15-mas), the populations of externalized ps-positive and pi-negative cells were 32.0% [2].
Einzelnachweise
[1] peraica m, radic b, lucic a, et al. toxic effects of mycotoxins in humans[j]. bulletin of the world health organization, 1999, 77(9): 754-766.
[2] lee d h, park t, kim h w. induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving parp in jurkat t cells through treatment with acetoxyscirpenol mycotoxins[j]. biological and pharmaceutical bulletin, 2006, 29(4): 648-654.

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Upstream-Materialien And Downstream Produkte

15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2623-22-5, 15-ACETOXY-3ALPHA,4BETA-DIHYDROXY-12,13-EPOXYTRICHOTHEC-9-ENE Verwandte Suche:

Send Inquriy