SOYASAPONIN I

Bezeichnung:SOYASAPONIN I

CAS-Nr51330-27-9

Englisch Name:SOYASAPONIN I

CBNumberCB5345670

SummenformelC48H78O18

Molgewicht943.13

MOL-Datei51330-27-9.mol

SOYASAPONIN I physikalisch-chemischer Eigenschaften

Schmelzpunkt	220-222 °C(Solv: methanol (67-56-1))
Siedepunkt	1024.2±65.0 °C(Predicted)
Dichte	1.41
storage temp.	2-8°C
Löslichkeit	ethanol: soluble1mg/mL, clear, colorless
pka	2.76±0.70(Predicted)
Aggregatzustand	powder
Farbe	White
Stabilität	Hygroscopic
InChIKey	PTDAHAWQAGSZDD-IOVCITQVSA-N

Sicherheit

WGK Germany	3
HS Code	29389090

SOYASAPONIN I Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Soyasaponin Bb is a triterpenoid saponin that has been found in soy and has enzyme inhibitory, antimetastatic, anti-inflammatory, and neuroprotective biological activities. It selectively inhibits human recombinant and porcine kidney renin (IC₅₀s = 30 and 30 μg/ml, respectively) over bovine trypsin, human urinary kallikrein, and rabbit angiotensin converting enzyme (ACE) when used at a concentration of 100 μg/ml. Soyasaponin Bb inhibits the mouse brain sialyltransferase ST3GAL1 (K_i = 2.1 μM) and decreases levels of α2,3-linked sialic acid on the cell surface and decreases migration of B16/F10 mouse melanoma cells in vitro when used at a concentration of 75 μM. It also dose-dependently increases viability and mRNA expression of heme oxygenase-1 (HO-1) in BRL 3A immortalized rat hepatocytes subjected to alcohol-induced oxidative stress. Soyasaponin Bb (10 mg/kg per day) increases the latency to enter the dark chamber in a passive avoidance test and the percentage of spontaneous alterations in the Y-maze test in a rat model of learning and memory impairment induced by ibotenic acid .
Verwenden
Soyasaponin I has been used:
- to test its effect on migration and invasion of ovarian cancer cell lines
- as standard for the quantification of saponins from quinoa and fenugreek samples
- as L-15 medium supplement for Zebrafish liver cell lines
Definition
ChEBI: Soyasaponin I is a triterpenoid saponin that is composed of soyasapogenol B having an alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucopyranosiduronic acid moiety attached at the 3-position via a glycosidic linkage. It has a role as a sialyltransferase inhibitor. It is a pentacyclic triterpenoid, a triterpenoid saponin, a trisaccharide derivative and a carbohydrate acid derivative. It is functionally related to a soyasapogenol B. It is a conjugate acid of a soyasaponin I(1-).
Allgemeine Beschreibung
Soyasaponin I is an oleanene-type triterpenoid aglycone and is a group B soyasaponin. It is an amphiphilic molecule and is metabolized by intestinal bacteria into sugars and aglycones.
Biochem/physiol Actions
Antioxidant and anti-inflammatory saponin found in soybean. Attenuates TNBS-induced colitis in mice. The structure consists of a glycoside moiety and triterpene derivative. Sialytransferase inhibitor and renin inhibitor.

SOYASAPONIN I Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

51330-27-9, SOYASAPONIN I Verwandte Suche:

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