CONDURITOL B EPOXIDE

Bezeichnung:CONDURITOL B EPOXIDE

CAS-Nr6090-95-5

Englisch Name:CONDURITOL B EPOXIDE

CBNumberCB5316315

SummenformelC6H10O5

Molgewicht162.14

MOL-Datei6090-95-5.mol

CONDURITOL B EPOXIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	157-159
Siedepunkt	360.5±42.0 °C(Predicted)
Dichte	1.925±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.	2-8°C
Löslichkeit	Soluble in Water (up to 25 mg/ml) or in DMSO
pka	13.08±0.70(Predicted)
Aggregatzustand	White solid
Farbe	White
Stabilität	Moisture Sensitive

Sicherheit

WGK Germany	3
Hazard Note	Harmful
HS Code	2932990090

Gefahreninformationscode (GHS)

CONDURITOL B EPOXIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Conduritol B epoxide (6090-95-5) is a β-Glycosidase inhibitor.1,2 May be used for generation of the “Gaucher mouse”3 and the in vitro model of the Gaucher cell4.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
inhibitor of glucosidases
Definition
ChEBI: 1-D-1,2-anhydro-myo-inositol is a conduritol epoxide resulting from the formal epoxidation of the double bond of (+)-conduritol B. It has a role as an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor and an EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor. It is functionally related to a (+)-conduritol B. It is an enantiomer of a 1-L-1,2-anhydro-myo-inositol.
Allgemeine Beschreibung
Conduritol B epoxide?(CBE) is a mix of 1-L-1,2-anhydro-myo-inositol and 1-D-1,2-anhydro-myo-inositol.
Biochem/physiol Actions
Conduritol B epoxide?(CBE)?is capable of inactivating sucrase-isomaltase irreversibly. It can be used to produce cell and animal models to study on Gaucher disease (GD) and Parkinson′s disease (PD).
Lager
Store at -20°C
Einzelnachweise
1) Datta and Radin (1988), Normalization of liver glucosylceramide levels in the “Gaucher” mouse by phosphatidylserine injection;? Biochem. Biophys. Res. Commun., 152 155 2) Radin and Vunnam (1981), Inhibitors of cerebroside metabolism;? Methods Enzymol., 72 673 3) Stephens et al. (1981), Distribution of conduritol B epoxide in the animal model for gaucher’s disease (Gaucher mouse); Biochim. Biophys. Acta, 672 29 4) Newburg et al. (1986), beta-Glucosidase inhibition in murine peritoneal macrophages by conduritol-B-epoxide: an in vitro model of the Gaucher cell;? Biochim. Biophys. Acta, 877 121

CONDURITOL B EPOXIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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