PURVALANOL A

Bezeichnung:PURVALANOL A

CAS-Nr212844-53-6

Englisch Name:PURVALANOL A

CBNumberCB5283664

SummenformelC19H25ClN6O

Molgewicht388.89

MOL-Datei212844-53-6.mol

PURVALANOL A physikalisch-chemischer Eigenschaften

Siedepunkt	590.5±60.0 °C(Predicted)
Dichte	1.33±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	methylene chloride: 50 mg/mL, clear, colorless
Aggregatzustand	powder
pka	14.51±0.10(Predicted)
Farbe	off-white
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Sicherheit

WGK Germany	3
HS Code	2933599590

Gefahreninformationscode (GHS)

PURVALANOL A Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Purvalanol A (212844-53-6) is a cyclin-dependent kinase inhibitor. IC50s= 4, 70, 35, 75 and 850 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk5/p35 and cdk4/cyclin D1 and respectively.1?Reversibly arrests synchronized cells in G1 and G2 phase.2?Induces ER stress-mediated apoptosis and autophagy in colon cancer cells.3?Suppresses Src-mediated transformation by inhibiting both CDKs and c-Src.4?In cells transformed with MYC, purvalanol A rapidly down-regulates survivin expression and induces MYC-dependent apoptosis.5?Cell permeable.
Verwenden
Purvalanol A acts as a potent, cell-permeable CDK inhibitor used in the treatment of cell proliferative disorders. Anti-cancer.
Definition
ChEBI: Purvalanol A is a purvalanol.
Biologische Aktivität
Cyclin-dependent kinase inhibitor. IC 50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.
Lager
Store at +4°C
Einzelnachweise
1) Gray?et al.?(1998),?Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors; Science,?281?533 2) Villerbu?et al.?(2002),?Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities; Int. J. Cancer,?97?761 3) Coker-Gurkan?et al.?(2015),?Purvalanol induces endoplasmic reticulum stress-mediated apoptosis and autophagy in a time dependent manner in HCT116 colon cancer cells; Oncol. Rep.,?33?2761 4) Hikita?et al.?(2010),?Purvalanol A, a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src; Genes Cells,?15?1051 5) Goga?et al.?(2007),?Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC; Nat. Med.,?13?820

PURVALANOL A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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