2-(chloroMethoxy)-2-Methylpropane

2-(chloroMethoxy)-2-Methylpropane Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  2-(chloroMethoxy)-2-Methylpropane (t-Butyl Chloromethyl Ether) is a reagent for introducing an acid-labile alcohol- or an imidazole-protecting group^[1].

• synthetische

  Preparative Methods of 2-(chloroMethoxy)-2-Methylpropane: chlorination of t-butyl methyl ether using NCS^[1], treatment of t-butyl methylthiomethyl ether with sulfuryl chloride^[2], or cleavage of t-butyl methoxymethyl ether with BCl3^[3].

• Synthesis Reference(s)

  Synthetic Communications, 16, p. 1607, 1986 DOI: 10.1080/00397918608056416

• Lager

  2-(chloroMethoxy)-2-Methylpropane solutions in CH2Cl2 appear to remain unchanged upon standing at rt for several days^[2]. Concentration apparently leads to decomposition. The structurally similar Chloromethyl Methyl Ether is a putative carcinogen.

• Einzelnachweise

  1. Pinnick, H. W.; Lajis, N. H. JOC 1978, 43, 3964.
  2. Jones, J. H.; Thomas, D. W.; Thomas, R. M.; Wood, M. E. SC 1986, 16, 1607.
  3. Goff, D. A.; Harris, R. N., III; Bottaro, J. C.; Bedford, C. D. JOC 1986, 51, 4711.

2-(chloroMethoxy)-2-Methylpropane Upstream-Materialien And Downstream Produkte

2-(chloroMethoxy)-2-Methylpropane Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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