Florantyrone Struktur

Florantyron

Bezeichnung:Florantyron

CAS-Nr519-95-9

Englisch Name:Florantyrone

CBNumberCB5239126

SummenformelC20H14O3

Molgewicht302.32

MOL-Datei519-95-9.mol

Synonyma

Florantyron

Florantyron physikalisch-chemischer Eigenschaften

Schmelzpunkt	184-187 °C(lit.)
Siedepunkt	574.2±33.0 °C(Predicted)
Dichte	1.367±0.06 g/cm3(Predicted)
CAS Datenbank	519-95-9(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	28-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	DV1761000
Giftige Stoffe Daten	519-95-9(Hazardous Substances Data)

Florantyrone Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Originator
Zanchol,Searle,US,1957
Definition
ChEBI: Florantyrone is a butanone.
Manufacturing Process
50 g of fluoranthene and 26 g of succinic anhydride in 500 cc of nitrobenzene were treated at 0°C to 5°C with 75 g of anhydrous aluminum chloride. The temperature was held at 0°C for 4 hours and then allowed gradually to come to room temperature. The reaction mixture was allowed to stand for 16 hours. The reaction mixture was then worked up. In so doing, the reaction mixture was decomposed with dilute HCl, the nitrobenzene was removed by steam distillation and the residue after filtration was dissolved in hot sodium carbonate solution and filtered free of a small amount of nonacidic material. Precipitation from solution with HCl gave a light yellow product which crystallized from a 50-50 mixture of dioxane alcohol as fine platelets which melted at 192°C to 194°C and showed a neutral equivalent of 308 which corresponds closely to the theoretical value of 302 for β-fluoranthoylpropionic acid.
25 g of the crude acid was dissolved in 100 cc of water containing 13 g of sodium carbonate. On cooling a thick syrup was obtained. On dilution to 1 liter precipitation started and after standing 16 hours, the solid which separated was filtered (filtrate treated as below), suspended in water, acidified with HCl and filtered. Crystallization from alcohol gave a light yellow material melting at 199°C to 200°C and having a neutral equivalent of 303.
The filtrate mentioned above, upon acidification thereof with HCl gave a darker acid which melted over a wide range, but had a neutral equivalent which also corresponds to that of β-fluoranthoylpropionic acid.
Therapeutic Function
Hydrocholeretic

Florantyrone Upstream-Materialien And Downstream Produkte

Florantyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

519-95-9, Florantyrone Verwandte Suche:

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