(5E,9E,13E)-6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetren-2-one

(5E,9E,13E)-6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetren-2-one Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  (5E,9E,13E)-Teprenone is an isomer of Teprenone (T103500), An anti-ulcerative. Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Reports indicate that Teprenone protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression.

• Definition

  ChEBI: Teprenone is a terpene ketone in which a (9E,13E)-geranylgernayl group is bonded to one of the alpha-methyls of acetone (it is a mixture of 5E- and 5Z-geoisomers in a 3:2 ratio). It has a role as an anti-ulcer drug, a cardioprotective agent, a hepatoprotective agent, a nephroprotective agent, a neuroprotective agent and a Hsp70 inducer. It is a methyl ketone and a terpene ketone. It contains a geranylgeranyl group.

• in vivo

  (5E,9E,13E)-Teprenone induces hat sock proteins accumulations in rat gastric mucosa^[1].
  

  Animal Model:	Male Wister strain rats (≈250 g)[1]
  Dosage:	200 mg/kg
  Administration:	Oral administration
  Result:	Caused accumulations of all of HSP90, HSP70, HSC70 and HSP60 within 60 minutes.

(5E,9E,13E)-6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetren-2-one Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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