AG 213

Bezeichnung:AG 213

CAS-Nr122520-86-9

Englisch Name:AG 213

CBNumberCB5152917

SummenformelC10H8N2O2S

Molgewicht220.25

MOL-Datei122520-86-9.mol

AG 213 physikalisch-chemischer Eigenschaften

Schmelzpunkt	213 °C
Siedepunkt	474.5±55.0 °C(Predicted)
Dichte	1.512±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: 50 mg/mL, clear, orange
pka	8.82±0.10(Predicted)
Aggregatzustand	Orange solid.

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
F	10

Gefahreninformationscode (GHS)

AG 213 Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC₅₀ value of 2.4 μM in the human epidermoid carcinoma cell line A431.
Verwenden
Tyrphostin 47 is a potent inhibitor of EGFR kinase activity.
Definition
ChEBI: 3-amino-2-[(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-3-mercapto-2-propenenitrile is a member of quinomethanes.
Biologische Aktivität
Epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC 50 values are 2.4 and 3 μ M respectively). Stimulates microtubule polymerization and promotes neurite outgrowth > 17-fold over basal conditions in vitro . Also weakly inhibits protein kinase C (IC 50 = 60 μ M).
Einzelnachweise
[1] romer l h, mclean n, turner c e, et al. tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells[j]. molecular biology of the cell, 1994, 5(3): 349-361.
[2] gazit a, yaish p, gilon c, et al. tyrphostins i: synthesis and biological activity of protein tyrosine kinase inhibitors[j]. journal of medicinal chemistry, 1989, 32(10): 2344-2352.
[3] levitzki a, gazit a. tyrosine kinase inhibition: an approach to drug development[j]. science, 1995, 267(5205): 1782.
[4] herbst r s. review of epidermal growth factor receptor biology[j]. international journal of radiation oncology biology physics, 2004, 59(2): s21-s26.

AG 213 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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