PL017

PL017 Chemische Eigenschaften,Einsatz,Produktion Methoden

• S-Sätze Betriebsanweisung:

  S22:Staub nicht einatmen.
  S24/25:Berührung mit den Augen und der Haut vermeiden.

• Biologische Aktivität

  PL-017 is a potent and selective μ opioid receptor agonist with IC50 of 5.5 nM for 125I-FK 33,824 binding to the μ site. PL-017 produces durable and reversible analgesia in rats.

• in vitro

  PL-017 has an IC ₅₀ of 10000 nM for ¹²⁵ I-DADLE binding to δ site.

• in vivo

  PL-017 (0.22, 0.45, 0.9 nmol/rat; icv) has the time of maximum effect of approximately 15 to 30 mm after injection at lower doses and produces analgesia lasting as long as 4 hours with larger doses in male Sprague-Dawley rats weighing 250 to 375 g.

• target

  IC50: 5.5 nM ( ¹²⁵ I-FK 33,824 binding to μ site)

PL017 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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