Quercetin-7-O-β-D-glucopyranoside

Bezeichnung:Quercetin-7-O-β-D-glucopyranoside

CAS-Nr491-50-9

Englisch Name:Quercetin-7-O-β-D-glucopyranoside

CBNumberCB51246345

SummenformelC21H20O12

Molgewicht464.38

MOL-Datei491-50-9.mol

Quercetin-7-O-β-D-glucopyranoside physikalisch-chemischer Eigenschaften

storage temp.	2-8°C
Löslichkeit	DMF: 10 mg/ml; DMSO: 10 mg/ml; PBS (pH 7.2): 0.3 mg/ml
Aggregatzustand	A crystalline solid
Siedepunkt	859.2±65.0 °C(Predicted)
Dichte	1.809±0.06 g/cm3(Predicted)
Schmelzpunkt	248 °C
pka	5.92±0.40(Predicted)
Farbe	White to yellow
LogP	-0.367 (est)

Quercetin-7-O-β-D-glucopyranoside Chemische Eigenschaften,Einsatz,Produktion Methoden

Occurrence
Quercimeritrin is a natural product found in Dendroviguiera sphaerocephala, Dendroviguiera eriophora, and other organisms with data available.
Definition
ChEBI: Quercetin-7-O-β-D-glucopyranoside is a quercetin O-glucoside in which a glucosyl residue is attached at position 7 of quercetin via a beta-glycosidic linkage. It has a role as an antioxidant and a metabolite. It is a beta-D-glucoside, a monosaccharide derivative, a member of flavonols, a tetrahydroxyflavone and a quercetin O-glucoside.
Antimicrobial activity
Quercetin-7-O-beta-D-glucopyranoside has antibacterial activity, it shows promising activity against Staphylococcus aureus. Quercetin 7-O-beta-D-glucopyranoside exhibits strong antioxidative, and anti-inflammatory activities, inhibiting expression of inducible nitric oxide synthase and release of nitric oxide by lipopolysaccharide-stimulated RAW 264.7 macrophages in a dose-dependent manner. It inhibits overexpression of cyclooxygenase-2 and granulocyte macrophage-colony-stimulating factor.
Biologische Aktivität
Quercetin-7-O-β-D-glucopyranoside is a flavonoid originally isolated from G. hirsutum that has diverse biological activities, including antioxidant, anti-inflammatory, and anti-angiogenic properties. It has antioxidant activity in a oxygen radical absorbance capacity (ORAC) assay and decreases tert-butyl hydroperoxide-induced reactive oxygen species (ROS) production in L-929 cells when used at concentrations of 0.25 and 1 μg/ml. Quercetin-7-O-β-D-glucopyranoside (15 and 30 μg/ml) reduces protein levels of inducible nitric oxide synthase (iNOS) and COX-2 in LPS-stimulated RAW 264.7 cells. It decreases angiogenesis in isolated rat aortic rings and proliferation of human umbilical vein endothelial cells (HUVECs) but has no effect on tube formation or chemotaxis of HUVECs when used at a concentration of 100 μM.

Quercetin-7-O-β-D-glucopyranoside Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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