sorivudine

sorivudine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Sorivudine is an orally-active antiviral nucleoside analog. It has potent and selective activity against herpes simplex virus type-1 (HSV-1) and varicella-zoster virus (VZV). In a cutaneous model infection of mice with HSV-1, oral administration of sorivudine at dose of 20 mg/kg resulted in a significant increase in the survival rate. Five percent sorivudine cream is also useful in the topical treatment of cutaneous HSV-1 infection, including immunocompromised patients. It has been suggested that its antiviral activity may be mediated by inhibition of DNA synthesis in virus infected cells.
  Since the metabolite of sorivudine inhibits the enzyme for pyrimidine catabolism, caution should be taken not to use sorivudine in combination with fluorouracil drugs in order to avoid hematological disorders.

• Originator

  Yamasa Shoyu (Japan)

• Verwenden

  Sorivudine is an antimetabolite drug and can be used to synthesize antiviral compounds as well as compounds that can treat diseases of viral etiol.

• Verwenden

  Antiviral.

• Definition

  ChEBI: Sorivudine is an organic molecular entity.

• Trademarks

  Bravavir (Bristol-Myers Squibb);Usevir.

sorivudine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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