Naratriptan Hydrochloride

Bezeichnung:Naratriptan Hydrochloride

Englisch Name:Naratriptan Hydrochloride

CBNumberCB4500391

SummenformelC17H25N3O2S.ClH

Molgewicht371.93

Naratriptan Hydrochloride physikalisch-chemischer Eigenschaften

Schmelzpunkt	234-236°C
storage temp.	-20°C Freezer
Löslichkeit	H2O: ≥10mg/mL
Aggregatzustand	powder
Farbe	white to off-white
InChIKey	AWEZYKMQFAUBTD-UHFFFAOYSA-N

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36
S-Sätze:	26
WGK Germany	3
HS Code	2935904000

Gefahreninformationscode (GHS)

Beschreibung
Naramig was launched in Germany, Sweden and the UK for use in migraine. It is chemically available via a number of related synthetic routes all having about three steps starting from 5-bromoindole. It is a new serotonin 5-HT_1B/1D receptor antagonist with modest affinity for 5-HT_1a, and very weak affinity for 5-HT₃ receptors. It has little or no affinity for a wide range of non-serotonin receptors including a- and padrenoceptors, dopamine, neurokinin NK₁, and opiate receptors. It mediates vasoconstriction in cerebral vasculature (extra cerebral intracranial vessels), reduces neurogenic inflammation, and inhibits responses mediated by the trigeminal nerves. It has a 6- and 3-fold greater affinity for 5-HT_1B, and 5-HT_1D, receptors, respectively, than sumatriptan which translates to a 2-3 fold increase in potency. The reoccurance of headache was less compared to sumatriptan, zolmitriptan and rizatriptan. Naramig had no clinical effects on blood pressure or heart rate, had a long duration of action with very good tolerability, and has high oral bioavailability.
Chemische Eigenschaften
Beige Solid
Originator
Glaxo Wellcome (UK)
Verwenden
laxative
Verwenden
Naratriptan Hydrochloride is a triptan drug that is used for the treatment of migraine headaches. It is a selective 5-hydroxytryptamine1 receptor subtype agonist
Verwenden
Naratriptan Hydrochloride is a triptan drug and is used for the treatment of migraine headaches
Trademarks
Amerge (GlaxoSmithKline).