PF-06446846 HYDROCHLORIDE

PF-06446846 HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  PF-06446846 hydrochloride is an orally active, highly selective translation inhibitor of the proprotein convertase subtilisin/kexin type 9 (PCSK9). It inhibits PCSK9 by inducing ribosome parking around codon 34.

• in vitro

  PF-06446846 inhibits the secretion of PCSK9 by Huh7 cells with an IC ₅₀ of 0.3 μM.

• in vivo

  PF-06446846 (oral gavage; 5-50 mg/kg/day for 14 days) lowers plasma PCSK9 in a dose-dependent manner and lowers total cholesterol levels.

  Animal Model:	Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing)
  Dosage:	5, 15, and 50 mg/kg
  Administration:	Oral gavage; daily for 14 days
  Result:	Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels.

• target

  PCSK9

PF-06446846 HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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