6-HYDROXYMELATONIN

Bezeichnung:6-HYDROXYMELATONIN

CAS-Nr2208-41-5

Englisch Name:6-HYDROXYMELATONIN

CBNumberCB4436858

SummenformelC13H16N2O3

Molgewicht248.28

MOL-Datei2208-41-5.mol

6-HYDROXYMELATONIN physikalisch-chemischer Eigenschaften

Schmelzpunkt	172-175°C
Siedepunkt	564.7±50.0 °C(Predicted)
Dichte	1.266±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
Löslichkeit	alcohol: soluble
Aggregatzustand	Solid
pka	10.12±0.40(Predicted)
Farbe	White to Beige
InChIKey	OMYMRCXOJJZYKE-UHFFFAOYSA-N

Sicherheit

Kennzeichnung gefährlicher	Xn,N
R-Sätze:	22-40-51/53-20
S-Sätze:	36/37-60
WGK Germany	3
RTECS-Nr.	AC3607000

Gefahreninformationscode (GHS)

6-HYDROXYMELATONIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
6-hydroxy Melatonin is an active metabolite of melatonin . It is formed from melatonin by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. 6-hydroxy Melatonin is a melatonin 1A (MT_1A), MT_1B, and MT₂ receptor agonist. It inhibits dopamine release from isolated rabbit retina (IC₅₀ = 0.0016 μM). 6-hydroxy Melatonin (10 and 100 μM) reduces increases in the levels of NF-κB, IL-6, and IL-8 and decreases in glutathione (GSH) levels in LPS- and peptidoglycan G-stimulated human umbilical vein endothelial cells (HUVECs) in an in vitro model of sepsis. It reduces iron-induced lipid oxidation in rat hippocampal homogenate when administered at a dose of 10 mg/kg.
Chemische Eigenschaften
Off-White to Pale Beige Solid
Verwenden
A metabolite of Melatonin (M215000).
Verwenden
A metabolite of Melatonin (S689050).
Verwenden
A major human metabolite of Melatonin
Verwenden
6-Hydroxymelatonin has been used as a melatonin derivative to test its protective effects in ultra violet B (UVB)-induced oxidative stress melanocytes and keratinocytes.
Definition
ChEBI: A member of the class of tryptamines that is melatonin with a hydroxy group substituent at position 6.
Allgemeine Beschreibung
6-Hydroxymelatonin (6-OHM) is a melatonin metabolite. It is produced in the liver by the action of cytochrome P450 enzyme as well as by photodegradation of melatonin. In the central nervous system, it exists as a sulfated form. 6-OHM is a partial melatonin receptor MT2 agonist.
Biochem/physiol Actions
6-Hydroxymelatonin (6-OHM) is an antioxidant with a free radical scavenging role. Like melatonin, it reduces the impact of UVB-induced oxidative stress in melanocytes. It also aids protection during iron (Fe2+)-induced neurotoxicity. 6-OHM effectively reduces lipid peroxidation and superoxide anion production induced by potassium cyanide (KCN).

6-HYDROXYMELATONIN Upstream-Materialien And Downstream Produkte

6-HYDROXYMELATONIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2208-41-5, 6-HYDROXYMELATONIN Verwandte Suche:

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