β-Boswellic Acid

Bezeichnung:β-Boswellic Acid

CAS-Nr631-69-6

Englisch Name:β-Boswellic Acid

CBNumberCB4427357

SummenformelC30H48O3

Molgewicht456.71

MOL-Datei631-69-6.mol

β-Boswellic Acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	130-135°C
alpha	D +107° (c = 0.75 in CHCl3)
Siedepunkt	556.0±50.0 °C(Predicted)
Dichte	1.09±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka	4.50±0.70(Predicted)
Aggregatzustand	Solid
Farbe	Off-White
Wasserlöslichkeit	practically insoluble in water
InChIKey	NBGQZFQREPIKMG-AKOQEMLPSA-N
LogP	9.105 (est)
CAS Datenbank	631-69-6

Sicherheit

WGK Germany

Gefahreninformationscode (GHS)

β-Boswellic Acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC₅₀ value of approximately 5 μM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid . It inhibits cell proliferation in HL-60 cells with IC₅₀ values of 3.7, 7.1, and 6.3 μM for DNA, RNA, and protein synthesis, respectively. In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS). It also increases calcium mobilization in platelets at concentrations ≥3 μM and induces platelet aggregation (EC₅₀ = 8 μM).
Chemische Eigenschaften
BETA-BOSWELLIC ACID is Off-White Solid
Verwenden
The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
Definition
ChEBI: Boswellic acid is a triterpenoid.
Anticancer Research
It is a natural pentacyclic triterpenediol and occurs in Boswellia serrata plants as anisomeric blend of 3α, 24-dihydroxyolean-12-ene and 3α, 24-dihydroxyurs-12-ene.It induces apoptosis in various cancer cells. The events involved in this process areexcessive reactive oxygen species (ROS), nitric oxide (NO) formation, DNA ladderformation, and increased sub-G0 phase in cell cycle. This ultimately results incleavage of Bcl-2 and translocation of Bax to mitochondria, which lead to the lossof mitochondrial potential and release of cyt-c and other factors into cytosol. All these events are linked with reduced expression of survivin and inhibitor of caspase-activatedDNases (ICAD) that leads to the activation of poly(ADP-ribose) polymerase(PARP). The triterpene upregulates the expression of cell death receptor-4(DR-4) and tumor necrosis factor receptor-1 (TNF-R1), where both lead to activationof caspase-8 (Huang et al. 2000; Desai et al. 2008; Lu et al. 2008).

β-Boswellic Acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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