Dibenz[a,h]anthracen

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H350：Kann Krebs verursachen.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P201：Vor Gebrauch besondere Anweisungen einholen.

  P273：Freisetzung in die Umwelt vermeiden.

  P308+P313：BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Dibenz[a,h]anthracene Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSES KRISTALLINES PULVER.

• ARBEITSPLATZGRENZWERTE

  TLV nicht festgelegt (ACGIH 2005).
  MAK nicht festgelegt (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch schnell erreicht werden.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Möglich sind Auswirkungen auf die Haut mit nachfolgender Photosensibilisierung. Wahrscheinlich krebserzeugend für den Menschen.

• LECKAGE

  Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Atemschutzgerät, P3-Filter für giftige Partikel.

• R-Sätze Betriebsanweisung:

  R45:Kann Krebs erzeugen.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
  R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
  R65:Gesundheitsschädlich: kann beim Verschlucken Lungenschäden verursachen.
  R38:Reizt die Haut.
  R11:Leichtentzündlich.

• S-Sätze Betriebsanweisung:

  S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
  S62:Bei Verschlucken kein Erbrechen herbeiführen. Sofort ärztlichen Rat einholen und Verpackung oder dieses Etikett vorzeigen.

• Beschreibung

  1, 2:5, 6-DIBENZANTHRACENE is a crystalline aromatic hydrocarbon. It is a component of coal tars, shale oils, and soots (IARC, 1985) and has been detected in gasoline engine exhaust, coke oven emissions, cigarette smoke, charcoal broiled meats, vegetation near heavily traveled roads, and surface water and soils near hazardous waste sites. It is a kind of carcinogenic compound, and thus being mainly used for the research purpose. For example, in biological research, it is a mutagen used to induce tumorigenesis.

• Chemische Eigenschaften

  Dibenz(a,h)anthracene is a colorless, crystal- line solid. PAHs are compounds containing multiple benzene rings and are also called polynuclear aromatic hydrocarbons.

• Chemische Eigenschaften

  white to light yellow crystalline solid

• Chemische Eigenschaften

  Dibenz[a,h]anthracene is a white crystalline solid. It is insoluble in water, slightly soluble in alcohol, and soluble in ether. This compound is incompatible with strong oxidizers.

• Physikalische Eigenschaften

  Colorless to pale yellow, monoclinic or orthorhombic crystals which with a faint, pleasant odor.

• Verwenden

  There is no report on the common use of dibenz[a,h]anthracene and its commercial production.

• Verwenden

  Dibenz[a,h]anthracene is a polycyclic aromatic hydrocarbon (PAH) and a known carcinogen. Dibenz[a,h]anthracene has produced positive results in bacterial DNA damage and mutagenicity assays and in mammalian cell DNA damage, mutagenicity and cell transformation assays.

• Definition

  ChEBI: Dibenz[a,h]anthracene is an ortho-fused polycyclic arene. It has a role as a mutagen.

• Vorbereitung Methode

  There is no commercial production or known use of this compound. It has been isolated from the coal tar pitch and is found in coke over effluents. It has been detected in urban atmospheres and occurs in tobacco smoke. Dibenz [a,h]anthracene is present as a minor component of the total PAH content in the environment. Human exposure occurs through smoking, inhaling of polluted air, and by ingesting food and water containing combustion products.

• Allgemeine Beschreibung

  White crystals or pale yellow solid. Sublimes.

• Air & Water Reaktionen

  Insoluble in water.

• Reaktivität anzeigen

  1,2:5,6-DIBENZANTHRACENE is incompatible with strong oxidizing agents. Is oxidized by chromic acid and by osmium tetraoxide .

• Health Hazard

  The toxicity of dibenz[a,h]anthracene is onthe same order as that of benz[a]anthracene.A lethal dose in mice by intravenous routeis 10 mg/kg. There is no report on its oraltoxicity. It is a mutagen. Its carcinogenicityin animals is well established, causing cancersin the lungs, liver, kidney, and skin.

• Brandgefahr

  Flash point data for 1,2:5,6-DIBENZANTHRACENE are not available; however, 1,2:5,6-DIBENZANTHRACENE is probably combustible.

• Sicherheitsprofil

  Confirmed carcinogen with experimental carcinogenic, tumorigenic, and neoplastigenic data. Poison by intravenous route. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

• mögliche Exposition

  Dibenz(a,h)anthracene is a chemical substance formed during the incomplete burning of fossil fuel, garbage, or any organic matter and is found in smoke in general; it condenses on dust particles and is distributed into water and soil and on crops. DB(a,h)A is a PAH and is also a component of coal tar pitch, which is used in industry as a binder for electrodes, and creosote is used to preserve wood. PAHs are also found in limited amounts in bituminous materials and asphalt used in industry and for paving.

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

• Carcinogenicity

  Based on no human data and sufficient data from animal assays, IRIS classifies dibenz [a,h]anthracene as a B2 carcinogen, a probable human carcinogen, and the IARC classifies dibenz[a,h]anthracene as a 2A carcinogen. Dibenz[a,h]anthracene produced carcinomas in mice following oral or dermal administration and injection site tumors in several species following s.c. or i.m. injection. It is also a tumor initiator.

• Source

  Constituent in coal tar, cigarette smoke (4 μg/1,000 cigarettes), and exhaust condensate of gasoline engine (96 μg/g) (quoted, Verschueren, 1983). Also detected in asphalt fumes at an average concentration of 12.25 ng/m³ (Wang et al., 2001).
  Based on laboratory analysis of 7 coal tar samples, dibenz[a,h]anthracene was not detected (EPRI, 1990). Lehmann et al. (1984) reported dibenz[a,h]anthracene concentrations of 0.03 mg/g and 1,300 mg/kg in a commercial anthracene oil and high-temperature coal tar, respectively. Identified in a high-temperature coal tar pitch used in roofing operations at concentrations ranging from 317 TO 1,680 mg/kg (Malaiyandi et al., 1982).
  Nine commercially available creosote samples contained dibenz[a,h]anthracene at concentrations ranging from 1 to 16 mg/kg (Kohler et al., 2000).
  Under atmospheric conditions, a low rank coal (0.5–1 mm particle size) from Spain was burned in a fluidized bed reactor at seven different temperatures (50 °C increments) beginning at 650 °C. The combustion experiment was also conducted at different amounts of excess oxygen (5 to 40%) and different flow rates (700 to 1,100 L/h). At 20% excess oxygen and a flow rate of 860 L/h, the amount of dibenz[a,h]anthracene emitted ranged from 32.0 ng/kg at 900 °C to 260.9 ng/kg at 750 °C. The greatest amount of PAHs emitted were observed at 750 °C (Mastral et al., 1999).

• Environmental Fate

  Biological. In activated sludge, <0.1% of the applied dibenz[a,h]anthracene mineralized to carbon dioxide after 5 d (Freitag et al., 1985). Based on aerobic soil die away test data, the estimated half-lives ranged from 361 to 940 d (Coover and Sims, 1987).
  Ye et al. (1996) investigated the ability of Sphingomonas paucimobilis strain U.S. EPA 505 (a soil bacterium capable of using fluoranthene as a sole source of carbon and energy) to degrade 4, 5, and 6-ringed aromatic hydrocarbons (10 ppm). After 16 h of incubation using a resting cell suspension, only 7.8% of dibenz[a,h]anthracene had degraded. It was suggested that degradation occurred via ring cleavage resulting in the formation of polar metabolites and carbon dioxide.
  Soil. The reported half-lives for dibenz[a,h]anthracene in a Kidman sandy loam and McLaurin sandy loam are 361 and 420 d, respectively (Park et al., 1990).
  Photolytic. A carbon dioxide yield of 45.3% was achieved when dibenz[a,h]anthracene adsorbed on silica gel was irradiated with light (λ >290 nm) for 17 h (Freitag et al., 1985). The photooxidation half-life in the atmosphere was estimated to range from 0.428 to 4.28 h (Atkinson, 1987).
  Chemical/Physical. Dibenz[a,h]anthracene will not hydrolyze because it does not contain a hydrolyzable functional group (Kollig, 1993).
  At influent concentrations of 1.0, 0.1, 0.01, and 0.001 mg/L, the GAC adsorption capacities were 69, 12, 2.1, and 0.39 mg/g, respectively (Dobbs and Cohen, 1980).

• Lager

  Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. See the entry on “Coal TarPitch Volatiles.” A regulated, marked area should be established where this chemical is handled, used, or stored incompliance with OSHA Standard 1910.1045

• Versand/Shipping

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

• läuterung methode

  The yellow-green colour (due to other pentacyclic impurities) is removed from it by crystallising from *benzene or by selective oxidation with lead tetraacetate in acetic acid [Moriconi et al. J Am Chem Soc 82 3441 1960]. [Beilstein 5 IV 2722.]

• Toxicity evaluation

  Dibenz[a,h]anthracene is largely associated with particulate matters, soils, and sediments. Its presence in places distant from primary sources indicates that it is reasonably stable in the atmosphere and capable of long-distance transport.
  Dibenz[a,h]anthracene can be adsorbed very strongly if released to the soil. However, no leaching to the groundwater or hydrolization or evaporation from soils surface is expected.With half-lives of 18 and 21 days, it is generally subjected to biodegradation in soil systems. Volatilization of dibenz[a,h] anthracene from wet soil surfaces is not expected to be an important fate process based on an estimated Henry’s Law constant of 7.3×10^-8 atm-m3 mol^-1. A biodegradation halflife of 750 days at 20°C after incubation with unacclimated soil microcosms indicates that biodegradation is not an important environmental fate process in soil.
  Dibenz[a,h]anthracene released to the atmosphere will likely be associated with particulate matter and may be subjected to moderately long-range transport, depending mainly on the particle size distribution and climatic conditions, which will determine the rates of wet and dry deposition. The estimated vapor pressure of 9.5×10¹⁰ mm Hg at 25°C of dibenz[a,h] anthracene indicates that this compound will exist solely in the particulate phase in the ambient atmosphere if released into air. Its presence in areas remote from primary sources demonstrates the potential for this long-range transport as well as dibenz[a,h]anthracene’s considerable stability in the air. Dibenz[a,h]anthracene absorbs solar radiation strongly, suggesting that it may be susceptible to direct photolysis in the environment. The estimated vapor phase half-life in the atmosphere is 1 day as a result of reaction with photochemically produced hydroxyl radicals.

• Inkompatibilitäten

  Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides.

• Waste disposal

  See the entry on Coal Tar Pitch Volatiles. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/ mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

• Einzelnachweise

  https://pubchem.ncbi.nlm.nih.gov/compound/Dibenz_a_h_anthracene#section=Top
  Heidelberger, Charles, and H. B. Jones. "The Distribution of Radioactivity in the Mouse Following Administration of Dibenzanthracene Labeled in the 9 and 10 Positions with Carbon Fourteen." Cancer1.2(2010):252.
  https://rais.ornl.gov/tox/profiles/dibenz_a_h_anthracene_c_V1.html

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