BEAUVERICIN

Bezeichnung:BEAUVERICIN

CAS-Nr26048-05-5

Englisch Name:BEAUVERICIN

CBNumberCB4345714

SummenformelC45H57N3O9

Molgewicht783.95

MOL-Datei26048-05-5.mol

BEAUVERICIN physikalisch-chemischer Eigenschaften

Schmelzpunkt	93-94℃
Siedepunkt	975.6±65.0 °C(Predicted)
Dichte	1.126±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Soluble in DMSO (30 mg/ml)
pka	-1.02±0.70(Predicted)
Farbe	White
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey	GYSCAQFHASJXRS-ABKJGVMTSA-N

Sicherheit

WGK Germany	3
HS Code	29419090

Gefahreninformationscode (GHS)

BEAUVERICIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Beauvericin (CAS 26048-05-5) induces apoptosis in A549 cancer cells.1 Disrupts mitochondrial volume regulation.2 Antifungal activity acting via inhibition of both multidrug efflux and TORC1 kinase.3 Crosses the blood-brain barrier in mice.4 Inhibits HIV-1 integrase.5
Chemische Eigenschaften
White powder
Verwenden
Toxic depsipeptide with antibiotic and insecticidal effects.Beauvericin is a toxic depsipeptide with antibiotic and insecticidal effects.
Verwenden
Beauvericin is a cyclic depsipeptide isolated from several fungal genera, notably Beauveria and Fusarium, first reported in 1969. Beauvericin exhibits broad antifungal, antibacterial, antiprotozoan and insecticidal activities. At the molecular level, beauvericin exhibits ionophoric properties, and inhibits acyl-CoA:cholesterol acyltransferase activity. Beauvericin induces apoptosis by elevating intracellular calcium levels.
Definition
ChEBI: A trimeric cyclodepsipeptide composed from alternating methylphenylalanyl and hydroxyvaleryl residues.
Einzelnachweise
1) Lu et al. (2016), Beauvericin-induced cell apoptosis through the mitogen-activated protein kinase pathway in human nonsmall cell lung cancer A549 cells.; J. Toxicol. Sci., 41 429 2) Tonshin et al. (2010), The Fusarium mycotoxins enniatins and beauvericin cause mitochondrial dysfunction by affecting the mitochondrial volume regulation, oxidative phosphorylation and ion homeostasis.; Toxicology, 276 49 3) Shekhar-Guturja et al. (2016), Dual action antifungal small molecule modulates multidrug efflux and TOR signaling; Nat. Chem. Biol., 12 867 4) Taevernier et al. (2016), Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins; Toxicol. Lett., 258 175 5) Shin et al. (2009), Beauvericin and enniatins H,I and MK1688 are new potent inhibitors of human immunodeficiency virus type-1 integrase; J. Antibiot. (Tokyo), 62 687

BEAUVERICIN Upstream-Materialien And Downstream Produkte

BEAUVERICIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

26048-05-5, BEAUVERICIN Verwandte Suche:

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