PROFOXYDIM-LITHIUM

Bezeichnung:PROFOXYDIM-LITHIUM

CAS-Nr139001-49-3

Englisch Name:PROFOXYDIM-LITHIUM

CBNumberCB4320465

SummenformelC24H32ClNO4S

Molgewicht466.03

MOL-Datei139001-49-3.mol

PROFOXYDIM-LITHIUM physikalisch-chemischer Eigenschaften

Schmelzpunkt	<25 °C
Siedepunkt	597.2±60.0 °C(Predicted)
Dichte	1.26±0.1 g/cm3(Predicted)
storage temp.	-70°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka	4.25±0.25(Predicted)
Aggregatzustand	buffered aqueous glycerol solution
Farbe	White to Off-White
Biologische Quelle	mouse
Specific Activity	62-84nmol/min·mg
Stabilität	Hygroscopic, Unstable in Solution
EPA chemische Informationen	Profoxydim (139001-49-3)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	21/22
S-Sätze:	36/37
WGK Germany	3

Gefahreninformationscode (GHS)

PROFOXYDIM-LITHIUM Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Profoxydim Lithium Salt is a salt of Profoxydim (139001-49-3) and an herbicide.
Definition
ChEBI: Profoxydim is a cyclic ketone that is 3-hydroxycyclohex-2-en-1-one substituted by a N-[2-(4-chlorophenoxy)propoxy]butanimidoyl group at position 2 and by a thian-3-yl group at position 5. It is a herbicide used for the control of grass weeds in rice. It has a role as a herbicide and an EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor. It is an oxime O-ether, a member of monochlorobenzenes, an aromatic ether, an enol, an organosulfur heterocyclic compound and a cyclic ketone.
Allgemeine Beschreibung
G-protein-coupled receptor kinase 2 (GRK2), which is officially known as adrenergic, beta, receptor kinase 1 (ADRBK1), gene codes for a 689 amino acid protein, that is of 79.573kDa. This gene has 12 catalytic region subdomains. GRK2 is expressed in the vascular endothelium, arterial smooth muscle, myocardium, kidney and in the renal proximal tubule. It is mapped to human chromosome 11q13.
Biochem/physiol Actions
G-protein-coupled receptor kinase 2 (GRK2) or ADRBK1 is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G protein-coupled receptors. GRK2 phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. RAF kinase inhibitor protein RKIP is a physiologic inhibitor of GRK2. After stimulation of G protein-coupled receptors, RKIP dissociates from its known target, RAF1 to associate with GRK2 and block its activity. G-protein-coupled receptor kinase 2 (GRK2) controls several intracellular mechanisms. It helps to maintain the structure and activities of the heart. Hence it participates in several cardiovascular diseases. GRK2 also modulates ion and fluid transport and eventually, blood pressure. It increases the synthesis of mitochondrial superoxide and reduces oxygen utilization and ATP synthesis. This protein serves as a major onco-modulator.

PROFOXYDIM-LITHIUM Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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