2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-

2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)- Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  KS370G is an inhibitor of UUO-induced renal fibrosis markers expression. It acts by attenuating collagen deposition in the obstructed kidney and significantly lowering the expression of renal inflammatory chemokines/adhesion molecules and monocyte cells marker.

• in vitro

  KS370G significantly inhibited the release of nitric oxide (NO) and the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Treatment with KS370G also induced heme oxygenase (HO)-1 and suppressors of cytokine signaling (SOCS)-3 expression in the microglia._x000D_ _x000D_ Reference: Mol Neurobiol. 2013 Dec;48(3):863-74. https://pubmed.ncbi.nlm.nih.gov/23801310/

• in vivo

  The results show that KS370G significantly attenuated collagen deposition in the obstructed murine kidney and inhibited UUO-induced renal fibrosis markers expression, including fibronectin, type I collagen, vimentin, and α-smooth muscle actin (α-SMA). KS370G significantly lowered the expression of renal inflammatory chemokines/adhesion molecules and monocyte cells marker (MCP-1, VCAM-1, ICAM-1 and CD11b)._x000D_ _x000D_ Reference: Eur J Pharmacol. 2015 Mar 5;750:1-7. https://pubmed.ncbi.nlm.nih.gov/25620133/

• target

  KS370G is an inhibitor of UUO-induced renal fibrosis markers expression.

2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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