7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL Struktur

7-Chlor-4-hydroxychinolin-2-carbonsure

Bezeichnung:7-Chlor-4-hydroxychinolin-2-carbonsure

Englisch Name:7-CHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID HCL

CBNumberCB4263777

SummenformelC10H6ClNO3

Molgewicht223.61

Synonyma

7-Chlor-4-hydroxychinolin-2-carbonsure

7-Chlor-4-hydroxychinolin-2-carbonsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	277-278 °C (decomp)
Siedepunkt	461.5±45.0 °C(Predicted)
Dichte	1.600±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	0.1 M NaOH: 13.7 mg/mL
Aggregatzustand	solid
pka	0.90±0.30(Predicted)
Farbe	tan
CAS Datenbank	18000-24-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Verwenden
NMDA receptor antagonist at the glycine site
Definition
ChEBI: A quinolinemonocarboxylic acid that is quinaldic acid which is substituted by a hydroxy group at position 4 and by a chlorine at position 7. It is a potent NMDA glutamate receptor antagonist which antagonizes the strychnine-insensitive glycine site of the MDA receptor. It also prevents neurodegeneration produced by quinolinic acid.
Biologische Funktion
Glycine B agonist site antagonist of N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of glutamate reuptake into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent analgesic effects in neurotransmission.
Biologische Aktivität
NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Also available as part of the NMDA Receptor - Glycine Site Tocriset™ .
in vivo
Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
Lager
Room temperature