Omadacycline Struktur

Omadacycline

Bezeichnung:Omadacycline

CAS-Nr389139-89-3

Englisch Name:Omadacycline

CBNumberCB42627315

SummenformelC29H40N4O7

Molgewicht556.65

MOL-Datei389139-89-3.mol

Omadacycline physikalisch-chemischer Eigenschaften

Siedepunkt	837.6±65.0 °C(Predicted)
Dichte	1.39±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	DMSO:1.0(Max Conc. mg/mL);1.8(Max Conc. mM)
Aggregatzustand	A crystalline solid
pka	4.50±1.00(Predicted)
Farbe	Yellow to orange
Stabilität	Hygroscopic
InChIKey	JEECQCWWSTZDCK-IQZGDKDPSA-N
SMILES	C1(=O)[C@]2(O)[C@@]([H])(C[C@@]3([H])C(=C2O)C(=O)C2=C(C(N(C)C)=CC(CNCC(C)(C)C)=C2O)C3)[C@H](N(C)C)C(O)=C1C(N)=O

Gefahreninformationscode (GHS)

Omadacycline Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Omadacycline, the drug that US FDA approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. It is not susceptible to common tetracycline-resistancemechanisms, and has demonstrated efficacy against a broad spectrum of pathogens including resistant isolates, which are increasing in prevalence and complexity.
Verwenden
Omadacycline is a potent an demonstrates efficacy against both Bacillus anthracis and Yersinia pestis; Also, it is a novel aminomethylcycline antibiotic in clinical development for community-acquired bacterial pneumonia (CABP).
Definition
ChEBI: Omadacycline is a member of tetracyclines.
Pharmakologie
Omadacycline has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections.The in vitro activity of Omadacycline against clinically relevant anaerobes was similar to that of tigecycline, with MIC90 values of 1 to 8 g/ml against Bacteroides spp, 0.5 g/ml against Clostridium difficile, Prevotella spp., and Porphyromonas asaccharolytica,1 g/ml against Peptostreptococcus spp, and 16 g/ml against Clostridium perfringens.
Nebenwirkungen
OMadacycline may cause serious adverse reactions including hypersensitivity reactions, tooth discoloration,Clostridioides difficile-associated diarrhea, and reversible inhibition of bone growth when administered during the second and third trimesters of pregnancy.Common adverse reactions include nausea, vomiting, infusion site reactions, alanine aminotransferase increased, aspartate aminotransferase increased, gamma-glutamyl transferase increased, hypertension, headache, diarrhea, insomnia, and constipation.Mild to moderate nausea and vomiting were the most frequent treatment-emergent adverse events in omadacycline (111 [30%] of 368 and 62 [17%] of 368, respectively) groups.

Omadacycline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

389139-89-3, Omadacycline Verwandte Suche:

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