CALMIDAZOLIUM CHLORIDE Struktur

Calmidazolium

Bezeichnung:Calmidazolium

CAS-Nr57265-65-3

Englisch Name:CALMIDAZOLIUM CHLORIDE

CBNumberCB4231628

SummenformelC31H23Cl7N2O

Molgewicht687.69

MOL-Datei57265-65-3.mol

Synonyma

Calmidazolium

Calmidazolium physikalisch-chemischer Eigenschaften

Schmelzpunkt	172-176 °C
storage temp.	2-8°C
Löslichkeit	Soluble to 100 mM in DMSO and to 100 mM in ethanol
Aggregatzustand	solid
Farbe	white
Wasserlöslichkeit	Soluble in dimethyl sulfoxide, ethanol. methanol, chloroform, and propylene glycol. Insoluble in water.
BRN	6470244

Sicherheit

S-Sätze:	22-24/25
RIDADR	UN 2811 6.1 / PGII
WGK Germany	3
RTECS-Nr.	Gk2402500
F	3-8-10
HS Code	29332990

Gefahreninformationscode (GHS)

CALMIDAZOLIUM CHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to off-white powder
Verwenden
Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+?transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+?influx distinct from store-operated Ca2+?entry and unaccompanied by Ca2+?store depletion, mobilizing stores and evoking a Ca2+?signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.
Allgemeine Beschreibung
Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.
Biologische Aktivität
Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca 2+ -transporting ATPase with IC 50 values of 0.15 and 0.35 μ M respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.
Biochem/physiol Actions
Inhibitor of calmodulin-regulated enzymes. It is also believed to directly block calcium channels in smooth muscle cells.
Lager
+4°C

Calmidazolium Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

57265-65-3, CALMIDAZOLIUM CHLORIDE Verwandte Suche:

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