D-erythro-C18-Dihydro-D-sphingosine Struktur

[R-(R,S)]-2-Aminooctadecan-1,3-diol

Bezeichnung:[R-(R*,S*)]-2-Aminooctadecan-1,3-diol

CAS-Nr764-22-7

Englisch Name:D-erythro-C18-Dihydro-D-sphingosine

CBNumberCB42130435

SummenformelC18H39NO2

Molgewicht301.51

MOL-Datei764-22-7.mol

Synonyma

[R-(R*,S*)]-2-Aminooctadecan-1,3-diol

[R-(R*,S*)]-2-Aminooctadecan-1,3-diol physikalisch-chemischer Eigenschaften

Schmelzpunkt	70-72°C
Siedepunkt	446.2±25.0 °C(Predicted)
Dichte	0.927±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO: soluble25mg/mL (warm)
pka	12.57±0.45(Predicted)
Aggregatzustand	White to off-white solid.
Farbe	white
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Sicherheit

WGK Germany

D-erythro-C18-Dihydro-D-sphingosine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1?and phospholipases A2 and D2.
Chemische Eigenschaften
White Powder
Verwenden
Sphinganine (d18:0) has been used:
- as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides
- as a medium supplement to test its effect on growth of yeast cells
- in the preparation of bovine serum albumin lipid complex to investigate its effect on non-lysosomal - glucosylceramidase β2 (GBA2) inhibition
Verwenden
Biosynthetic precursor of Sphingosine. Inhibits protein kinase C.
Definition
ChEBI: Sphinganine is a 2-aminooctadecane-1,3-diol having (2S,3R)-configuration. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a human metabolite and a mouse metabolite. It is a conjugate base of a sphinganine(1+).
Allgemeine Beschreibung
Sphinganine (d18:0) is a substrate for the enzyme ceramide desaturase. It is synthesized indirectly due to the interconversion of supplemented glycine to serine. Sphinganine (d18:0) is catabolized to ceramide.
Biochem/physiol Actions
Sphinganine (d18:0) levels are not altered in hereditary sensory neuropathy type 1 cells. Accumulation of d18:0 is observed in tumor hypoxia. It is useful as a biomarker for studying microbial diversity.
Einzelnachweise
1) Merrill?et al. (1989),?Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for cellular effects of these compounds; Biochemistry,?28?3138 2) Franson?et al. (1992),?Sphingolipid metabolism and signal transduction: inhibition of in vitro phospholipase activity by sphingosine, Biochim. Biophys. Acta?1136?169

[R-(R,S)]-2-Aminooctadecan-1,3-diol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

764-22-7, D-erythro-C18-Dihydro-D-sphingosine Verwandte Suche:

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[R-(R*,S*)]-2-Aminooctadecan-1,3-diol

D-erythro-C18-Dihydro-D-sphingosine Chemische Eigenschaften,Einsatz,Produktion Methoden

[R-(R*,S*)]-2-Aminooctadecan-1,3-diol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

764-22-7, D-erythro-C18-Dihydro-D-sphingosine Verwandte Suche:

[R-(R,S)]-2-Aminooctadecan-1,3-diol

[R-(R,S)]-2-Aminooctadecan-1,3-diol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.