H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2 Struktur

H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2

Bezeichnung:H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2

CAS-Nr258276-95-8

Englisch Name:H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2

CBNumberCB4178660

SummenformelC64H109N19O24S

Molgewicht1560.73

MOL-Datei258276-95-8.mol

H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2 physikalisch-chemischer Eigenschaften

Siedepunkt	2035.4±65.0 °C(Predicted)
Dichte	1.372±0.06 g/cm3(Predicted)
storage temp.	−20°C
Löslichkeit	insoluble in EtOH; ≥156 mg/mL in DMSO; ≥24.15 mg/mL in H2O
Aggregatzustand	white powder
pka	4.44±0.10(Predicted)
Farbe	White to off-white
Sequenz	H-Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-OH

Sicherheit

WGK Germany

H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biologische Aktivität
leptin (116-130), amide, mouse(c64h109n19o24s),a peptide with the sequence ser-cys-ser-leu-pro-gln-thr-ser-gly-leu-gln-lys-pro-glu-ser-nh2. leptin is an adipocyte-derived hormone that acts as a major regulator for food intake and energy homeostasis. leptin deficiency or resistance can result in profound obesity, diabetes, and infertility in humans. since the discovery of leptin, the breadth of biological actions has dramatically expanded and served to broaden the initial perspective, where this protein was viewed solely as an antiobesity hormone. important biological activities have been discovered in peripheral tissues that demonstrate the pleiotropic effects of this molecule in such areas as hematopoiesis, angiogenesis, blood pressure, bone mass, lymphoid organ homeostasis, and t lymphocyte function. recent data indicate that leptin(116-130), an active fragment of the native molecule, exerts effects similar to those of the native peptide on body weight and food intake.figure1 formula of leptin (116-130)figure2 signal transduction pathways of leptin
Einzelnachweise
1. Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW (May 1997). "Crystalstructure of the obese protein leptin-E100". Nature 387 (6629): 206–9.2. Brennan AM, Mantzoros CS (June 2006). "Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications". Nat Clin Pract Endocrinol Metab 2 (6): 318–327. 3. GreGreen ED, Maffei M, Braden VV, Proenca R, DeSilva U, Zhang Y, Chua SC Jr, Leibel RL, Weissenbach J, Friedman JM (August 1995). "The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7". Genome Res. 5 (1): 5–12.4. Margetic S, Gazzola C, Pegg GG, Hill RA (2002). "Leptin: a review of its peripheral actions and interactions". Int. J. Obes. Relat. Metab. Disord. 26 (11): 1407–1433.

H-SER-CYS-SER-LEU-PRO-GLN-THR-SER-GLY-LEU-GLN-LYS-PRO-GLU-SER-NH2 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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