Pemetrexed Struktur

Pemetrexed

Bezeichnung:Pemetrexed

CAS-Nr137281-23-3

Englisch Name:Pemetrexed

CBNumberCB4170583

SummenformelC20H21N5O6

Molgewicht427.41

MOL-Datei137281-23-3.mol

Pemetrexed physikalisch-chemischer Eigenschaften

Dichte	1.59±0.1 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
Löslichkeit	slightly sol. in Methanol
Aggregatzustand	powder to crystal
pka	3.58±0.10(Predicted)
Farbe	White to Blue
Merck	14,7077
CAS Datenbank	137281-23-3(CAS DataBase Reference)

Sicherheit

RTECS-Nr.	LZ9950100
HS Code	2933.99.9701
Giftige Stoffe Daten	137281-23-3(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Pemetrexed Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt is Off-White Solid
Verwenden
Pemetrexed is used in the treatment of malignant pleural mesothelioma (MPM) and erectile dysfunction therapy.
Definition
ChEBI: Pemetrexed is an N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). It has a role as an antineoplastic agent, an antimetabolite, an EC 2.1.1.45 (thymidylate synthase) inhibitor, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor. It is a pyrrolopyrimidine and a N-acyl-L-glutamic acid. It is a conjugate acid of a pemetrexed(2-).
Trademarks
Alimta (Lilly).
Nebenwirkungen
The most common side effects for pemetrexed include fatigue, nausea, vomiting, anorexia, mucositis, myelosuppression ± infection, bleeding, rash, diarrhea and ↑ LFTs.
Severe myelosuppression is often dose-limiting for pemetrexed. Sepsis, in some cases fatal, have occurred in approximately 1% of patients in clinical trials. Prophylactic folic acid and intramuscular vitamin B12 supplements are necessary to reduce hematologic or non-hematologic toxicities.
Pemetrexed may cause serious and in some cases fatal dermatologic toxicities. Rarely, StevensJohnson syndrome and toxic epidermal necrolysis have been reported.
Lager
Store at +4°C
Mode of action
Pemetrexed is a pyrrolopyrimidine antifolate that exerts its antineoplastic activity by inhibiting thymidylate synthase (TS), glycinamide ribonucleotide formyltransferase (GARFT) and dihydrofolate reductase (DHFR), which are involved in folate metabolism and DNA synthesis, resulting in inhibition of purine and thymidine nucleotide synthesis.

Pemetrexed Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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