PENITREM A Struktur

PENITREM A

Bezeichnung:PENITREM A

CAS-Nr12627-35-9

Englisch Name:PENITREM A

CBNumberCB4155421

SummenformelC37H44ClNO6

Molgewicht634.2

MOL-Datei12627-35-9.mol

PENITREM A physikalisch-chemischer Eigenschaften

Schmelzpunkt	238°C
Dichte	1.0241 (rough estimate)
Brechungsindex	1.6000 (estimate)
storage temp.	2-8°C
Löslichkeit	Soluble in DMSO (up to 6 mg/ml)
Aggregatzustand	White solid.
pka	13.22±0.70(Predicted)
Farbe	Amorphous solid
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

Kennzeichnung gefährlicher	T+,T
R-Sätze:	26/27/28
S-Sätze:	36/37/39-45
RIDADR	UN 2811 6.1/PG 2
WGK Germany	3
RTECS-Nr.	RY7535000
HazardClass	6.1(a)
PackingGroup	II
HS Code	29349990
Toxizität	LD50 orl-mus: 10 mg/kg 41KEAL -,108,78

Gefahreninformationscode (GHS)

PENITREM A Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Penitrem A (12627-35-9) is a fungal mycotoxin that acts as a selective, irreversible blocker of the smooth muscle high conductance Ca2+-activated K+?(BK, KCa1.1) channel (100% block at 10 nM).1?Displays brain neurotoxicity in rats along with dose-dependent convulsions and death.2?An important tool for studying the role of BK channels in vascular function which is effective in cellular, tissue and?in vivo?experiments.3?Inhibits BK channels in inside-out and cell-attached patches, whereas iberiotoxin (considered the gold standard BK channel blocker) does not.3?May be used to partially ablate Purkinje cells in immature rat cerebellum providing a model for neural stem cell transplantation studies.4
Chemische Eigenschaften
Solid
Occurrence
A series of closely related metabolites of Penicillium crustosum has recently been isolated and the components separated chromatographically. Penitrem A forms colourless crystals from EtOH.
Verwenden
Penitrem A is a tremorgenic mycotoxin isolated from Penicillium species. Penitrem A is a selective blocker of high-conductance Ca2+-activated potassium channels.
Verwenden
Penitrem A has been used as Ca²⁺-Activated K⁺ (BK) channel blocker to study its effect on BK current in bag cell neurons.
Definition
ChEBI: Penitrem A is an organooxygen compound and an organic heterotricyclic compound.
Biochem/physiol Actions
Penitrem A intoxication causes ataxia, polypnea, and sustained tremors and may lead to seizures and death. Penitrem A affects the central and peripheral nervous system. It impairs the GABAergic neurotransmission in the cerebellum.
Sicherheitsprofil
Poison by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Clí and NOx.
Lager
-20°C
Einzelnachweise
References/Citations:

PENITREM A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

12627-35-9, PENITREM A Verwandte Suche:

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