2-CHLORO-4-PHENYLQUINAZOLINE

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

• Sicherheit

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-CHLORO-4-PHENYLQUINAZOLINE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  2-CHLORO-4-PHENYLQUINAZOLINE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

• Verwenden

  2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.

• Synthese

  
  A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).

2-CHLORO-4-PHENYLQUINAZOLINE Upstream-Materialien And Downstream Produkte

2-CHLORO-4-PHENYLQUINAZOLINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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