bruceine A Struktur

bruceine A

Bezeichnung:bruceine A

CAS-Nr25514-31-2

Englisch Name:bruceine A

CBNumberCB41382240

SummenformelC26H34O11

Molgewicht522.54

MOL-Datei25514-31-2.mol

bruceine A physikalisch-chemischer Eigenschaften

Siedepunkt	712.6±60.0 °C(Predicted)
Dichte	1.43±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	insoluble in EtOH; insoluble in H2O; ≥5.23 mg/mL in DMSO with gentle warming
Aggregatzustand	Powder
pka	8.81±0.70(Predicted)
Farbe	White to off-white

bruceine A Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the fruit of bruce chinensis.
Verwenden
Bruceantin A acts as an anti-babesial quassinoid, extracted from the fruits of Brucea javanica, also an effective anti-trypanosomal agent in vitro. Cytotoxic agent.
Definition
ChEBI: Bruceine A is a quassinoid.
Biologische Aktivität
ic50: 7.7 nm against the parasitescanine babesiosis is a tick-borne disease caused by the intraerythrocytic apicomplexan parasites, babesia gibsoni and b. canis. clinical signs of b. gibsoni infection are anemia, fever, thrombocytopenia, splenomegaly, lymphadenopathy, and lethargy. bruceine a, a natural quassinoid compound extracted from the brucea javanica (l.) merr. dried fruits, was reported to have antibabesial activity.
Physiological effects
Bruisein A has an effect of treating malignant tumor, antimalarial and anti-inflammatory.
in vitro
bruceine a inhibited the in-vitro babesia gibsoni growth in canine erythrocytes at lower concentration compared with the antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nm [1].
in vivo
oral administration of bruceine a at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog. an untreated dog developed typical acute babesiosis symptoms including high fever, severe anemia, and complete loss of appetite and movement. however, the two bruceine a-treated dogs maintained their healthy conditions throughout the experimental period of 4 weeks [1].
target
Antifection | p65 | NF-kB | ROS
Einzelnachweise
[1] nakao r, mizukami c, kawamura y, subeki, bawm s, yamasaki m, maede y, matsuura h, nabeta k, nonaka n, oku y, katakura k. evaluation of efficacy of bruceine a, a natural quassinoid compound extracted from a medicinal plant, brucea javanica, for canine babesiosis. j vet med sci. 2009 jan;71(1):33-41.

bruceine A Upstream-Materialien And Downstream Produkte

bruceine A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

25514-31-2, bruceine A Verwandte Suche:

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