Colestipol HCl

Gefahreninformationscode (GHS)

• Alarmwort

  Warnung

Colestipol HCl Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Colestid,Upjohn,US,1977

• Verwenden

  Antihyperlipidemic.

• Manufacturing Process

  Into a 1,000 gallon, jacketed, glass-lined reactor equipped with baffles and a two-speed (67 and 135 rpm) reversed impeller is introduced 200 g of Richonate 60B (a 60% aqueous slurry of sodium salts of alkylbenzenesulfonic acids) and 364 liters of deionized water, followed by 90.5 kg of tetraethylenepentamine rinsed in with 5 gallons of toluene. The solution is stirred at the low speed and then 500 gallons of toluene are added to form a dispersion. To the stirred dispersion is added 109 kg of epichlorohydrin, rinsed in with 5 gallons of toluene, and the resulting mixture is heated at reflux for two hours. The reaction mixture is cooled to about 20°C and then treated with 58.5 kg of a filtered 50% aqueous solution of sodium hydroxide. The mixture is removed from the reactor and filtered, and the copolymer is collected and dried by treating it first with hot (75°C to 80°C) filtered nitrogen and then with an 80°C air stream. The resulting crude product is returned to the reactor, washed extensively with filtered deionized water (at the low speed), dried with an 80°C air stream and blended until homogeneous to give about 155 kg of a dry tetraethylenepentamine-epichlorohydrin copolymer hydrochloride, particle diameter 0.002-0.02 inch.

• Trademarks

  Colestid (Pharmacia & Upjohn).

• Therapeutic Function

  Antihyperlipoproteinemic

Colestipol HCl Upstream-Materialien And Downstream Produkte

Colestipol HCl Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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