Nafiverin

nafiverine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Naftidan,De Angeli,Italy,1969

• Definition

  ChEBI: Nafiverine is a member of naphthalenes.

• Manufacturing Process

  15 grams of α-methyl-1-naphthylacetic acid were refluxed with 50 ml of thionyl chloride during 3 hours. The excess thionyl chloride was removed under reduced pressure and the product was also isolated by distillation under reduced pressure. Yield: 15.6 grams (96%). The α-methyl-1-naphthyl acetyl chloride boils at 120° to 124°C. 1.76 grams of N,N'-di-(β-hydroxyethyl)- piperazine, 1.9 grams of sodium bicarbonate and 4.45 grams of α-methyl-1- naphthyl acetyl chloride in 30 ml of anhydrous acetonitrile were refluxed with stirring during 5 hours. After cooling the mixture was filtered and the acetonitrile evaporated off under reduced pressure. 5.2 grams of crude ester were obtained. The hydrochloride, melting at 220° to 221°C, may be prepared by dissolving the ester in absolute ethanol and treating the solution with anhydrous gaseous hydrogen chloride.

• Therapeutic Function

  Spasmolytic

nafiverine Upstream-Materialien And Downstream Produkte

Nafiverin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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