ALK5 inhibitor II

Bezeichnung:ALK5 inhibitor II

CAS-Nr446859-33-2

Englisch Name:ALK5 inhibitor II

CBNumberCB3806232

SummenformelC17H13N5

Molgewicht287.32

MOL-DateiMol file

ALK5 inhibitor II physikalisch-chemischer Eigenschaften

Schmelzpunkt	195 °C
Siedepunkt	501.9±50.0 °C(Predicted)
Dichte	1.296±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: >20mg/mL
Aggregatzustand	Yellow solid
pka	10.05±0.50(Predicted)
Farbe	Pale yellow
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey	LBPKYPYHDKKRFS-UHFFFAOYSA-N

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	45
RIDADR	UN 2811
WGK Germany	3

Gefahreninformationscode (GHS)

ALK5 inhibitor II Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
RepSox (446859-33-2) is a potent (IC50?ALK5 auto-P= 4 nM; IC50?TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1?RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2?It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4
Verwenden
Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.
Verwenden
RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.
Definition
ChEBI: 1,5-naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl]- is a pyrazolopyridine.
Biochem/physiol Actions
RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).
Lager
+4°C
Einzelnachweise
1) Gellibert?et al. (2004),?Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors; J. Med. Chem.?47?4494 2) Ichida?et al.?(2009),?A Small-molecule Inhibitor of TGF-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog; Cell Stem Cell?5?491 3) Cheng?et al.?(2015),?Direct Conversion of astrocytes into neuronal cells by a drug cocktail;?Cell Res.?25?1269 4) Cheng?et al.?(2014),?Generation of neural progenitor cells by chemical cocktails and hypoxia; Cell Res.?24?665

ALK5 inhibitor II Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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