H-7 DIHYDROCHLORIDE

H-7 DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• S-Sätze Betriebsanweisung:

  S24/25:Berührung mit den Augen und der Haut vermeiden.

• Chemische Eigenschaften

  White Crystalline Solid

• Verwenden

  A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases

• Verwenden

  H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

• Definition

  ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.

• Allgemeine Beschreibung

  A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (K_i = 97 μM), protein kinase A (K_i = 3.0 μM), protein kinase C (K_i = 6 μM), and protein kinase G (K_i = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.

• Biochem/physiol Actions

  Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively

• Lager

  Store at RT

H-7 DIHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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