5-Chloro-2-fluorophenylboronic acid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P304+P340：BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

  P405：Unter Verschluss aufbewahren.

5-Chloro-2-fluorophenylboronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  suzuki reaction

• Verwenden

  Reactant involved in:
  
  • Suzuki cross-coupling reactions
  • Synthesis of biaryl amides with muscarinic acetylcholine receptor subtype M1 agonistic activity
  • Synthesis of kinesin spindle protein inhibitors
  • GABA α2/3 agonist preparation

• Synthese

  To a solution of 2-bromo-4-chloro-1-fluorobenzene (5 g, 0.0238 mol) in anhydrous ether (30 ) at -70C under nitrogen atmosphere was added a 2M solution of n-BuLi in hexane (13 mL, 0.0262 mol). mL) in anhydrous ether (30 ) was added to a 2 M solution of n-BuLi in hexane (13 mL, 0.0262 mol). The solution was stirred at the same temperature for 30 min and then triisopropyl borate (4.93 g,0.0262 mol) was added dropwise to the solution. The white slurry formed was stirred at -70 C for 30 min and then warmed to room temperature and stirred for 1 h. The reaction was monitored by TLC and H NMR to monitor the reaction. After the reaction was completed, the reaction mixture was hydrolyzed with 6N NaOH and stirred for 1 h. The reaction mixture was extracted with EtOAc. The organic layer was washed with brine and concentrated under reduced pressure to obtain a viscous compound, which was ground with n-pentane and dried to obtain 5-chloro-2-fluorophenylboronic acid as an off-white solid.

5-Chloro-2-fluorophenylboronic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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