NEMONAPRIDE Struktur

NEMONAPRIDE

Bezeichnung:NEMONAPRIDE

CAS-Nr75272-39-8

Englisch Name:NEMONAPRIDE

CBNumberCB3492220

SummenformelC21H26ClN3O2

Molgewicht387.9

MOL-Datei75272-39-8.mol

NEMONAPRIDE physikalisch-chemischer Eigenschaften

Schmelzpunkt	152-153°C
storage temp.	Store at RT
Löslichkeit	Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	White to Off-White
CAS Datenbank	75272-39-8

Gefahreninformationscode (GHS)

NEMONAPRIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Nemonapride is a potent dopamine D₂receptor antagonist antipsychotic reported to have superior efficacy against hallucinations and delusions and also to be effective in the treatment of negative symptoms. The compound is a benzamide diastereomer and, although more potent than haloperidol, side effects are reported to be few primarily akinesia and some muscle rigidity with extrapyramidal symptoms being rare.
Beschreibung
Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals. It binds dopamine 2 (D₂)-like receptors preferentially over D₁-like receptors (K_is = 0.06, 0.3, and 0.15 nM for D₂, D₃, and D₄, respectively). Nemonapride also binds sigma 1 (σ1) and σ2 receptors (K_is = 8.4 and 9.6 nM, respectively) and activates the serotonin 1A receptor (5-HT_1A; IC₅₀ = 34 nM).
Chemische Eigenschaften
Colourless Crystalline Solid
Originator
Yamanouchi (Japan)
Verwenden
Nemonapride is a selective dopamine D2 receptor antagonist. Nemonapride is used as an antipsychotic.
Verwenden
A selective dopamine D2 receptor antagonist. Used as an antipsychotic
Definition
ChEBI: (2R,3R)-nemonapride is an optically active form of nemonapride having (2R,3R)-configuration. It is a conjugate base of a (2R,3R)-nemonapride(1+). It is an enantiomer of a (2S,3S)-nemonapride.
Trademarks
Emirace
Biologische Aktivität
Highly potent dopamine D 2 -like receptor antagonist; selective over D 1 -like receptors (K i values are 0.1 and 740 nM for D 2 -like and D 1 -like receptors respectively). Also potent 5-HT 1A receptor agonist (IC 50 = 34 nM) and has affinity for sigma receptors.
Lager
Store at RT

NEMONAPRIDE Upstream-Materialien And Downstream Produkte

NEMONAPRIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

75272-39-8, NEMONAPRIDE Verwandte Suche:

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