Dibenzo[def,p]chrysen

Bezeichnung:Dibenzo[def,p]chrysen

CAS-Nr191-30-0

Englisch Name:DIBENZO(A,I)PYRENE

CBNumberCB3451069

SummenformelC24H14

Molgewicht302.37

MOL-Datei191-30-0.mol

Synonyma

Dibenzo[def,p]chrysen

Dibenzo[def,p]chrysen physikalisch-chemischer Eigenschaften

Schmelzpunkt	228.05°C
Siedepunkt	378.4°C (rough estimate)
Dichte	1.1762 (estimate)
Brechungsindex	1.9130 (estimate)
storage temp.	2-8°C
Löslichkeit	Chloroform (Very Slightly, Heated), Dichloromethane (Slightly, Heated)
Farbe	Yellow to Orange
BRN	2054068
Stabilität	Stable, but may be heat sensitive - keep cool. Combustible. Incompatible with strong oxidizing agents.
IARC	2A (Vol. Sup 7, 92) 2010
EPA chemische Informationen	Dibenzo[a,l]pyrene (191-30-0)

Sicherheit

Kennzeichnung gefährlicher	Xn,T
R-Sätze:	40-67-36/37/38-45-41-52/53
S-Sätze:	23-24/25-36/37-45-26-53-39-61
RIDADR	2811
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III
Giftige Stoffe Daten	191-30-0(Hazardous Substances Data)

Gefahreninformationscode (GHS)

DIBENZO(A,I)PYRENE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
S-Sätze Betriebsanweisung:
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
Yellow Solid
Verwenden
An active metabolite from inhalation and dermal exposure to polycyclic aromatics hydrocarbons in hot mix asphalt paving workers. DBC is the most potent tumorigen that has been identified to date. Dib enzo[def,p]chrysene (DBC) is a carcinogen and should be handled with appropriate caution.
Definition
ChEBI: Dibenzo[a,l]pyrene is an ortho- and peri-fused polycyclic arene. It has a role as a mutagen and a human metabolite.
Allgemeine Beschreibung
Yellow odorless crystals or flakes. Water insoluble.
Air & Water Reaktionen
Dust/air mixtures may ignite and explode. Insoluble in water.
Reaktivität anzeigen
Vigorous reactions, sometimes amounting to explosions, can result from the contact between aromatic hydrocarbons, such as DIBENZO(A,I)PYRENE, and strong oxidizing agents. They can react exothermically with bases and with diazo compounds. Substitution at the benzene nucleus occurs by halogenation (acid catalyst), nitration, sulfonation, and the Friedel-Crafts reaction.
Sicherheitsprofil
Confirmed carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes.
Carcinogenicity
Dibenzo[a,1]pyrene is a class 2B carcinogen according to the IARC, although recent data suggest that it is a 2A carcinogen. In mouse studies, it has been more potent than benzo[a]pyrene in skin, and in rat studies, it has been more potent than 7,12-dimethylbenz [a]anthracene in the mammary gland. Dibenzo[a,l]pyrene was tested for carcinogenicity in studies of single and repeated dermal application to mice, as well as several initiation–promotion studies on mouse skin; all studies gave positive results. Dibenzo[a,l] pyrene also induced oral cavity tumors when applied dermally to the tongue of hamsters and lung tumors in mice following intraperitoneal injection. In addition to lung tumors, dibenzo[a,l]pyrene induced hepatic tumors and a variety of tumors at other sites when administered intraperitoneally to newborn mice. Multiple tumor sites were also observed following intragastric application of dibenzo[a,l]pyrene in mice. Intramamillary administration to rats also yielded positive results. Furthermore, two studies on fish demonstrated that nonmammalian species are also susceptible to dibenzo[a,l]pyreneinduced tumorigenicity.The most active metabolite is the potent 11,12-dihydrodiol of dibenzo[a,1] pyrene.

Dibenzo[def,p]chrysen Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

191-30-0, DIBENZO(A,I)PYRENE Verwandte Suche:

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