MI-192 Struktur

MI-192

Bezeichnung:MI-192

CAS-Nr1415340-63-4

Englisch Name:MI-192

CBNumberCB33039886

SummenformelC24H21N3O2

Molgewicht383.44

MOL-Datei1415340-63-4.mol

MI-192 physikalisch-chemischer Eigenschaften

Siedepunkt	565.0±50.0 °C(Predicted)
Dichte	1.30±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	≤5mg/ml in DMSO;1mg/ml in dimethyl formamide
pka	13.08±0.70(Predicted)
Aggregatzustand	powder
Farbe	white to light brown

MI-192 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
MI-192 is a histone deacetylase (HDAC) 2 and 3 inhibitor. It also showed cytotoxic effect by inducing differentiation and apoptosis in acute myeloid leukemia cells in human.
Biologische Aktivität
mi-192 is a histone deacetylases (hdacs) inhibitor that preferentially inhibits hdac2 and hdac3 with ic50 values of 30 nm and 16 nm, respectively [1].histone acetylation is the most commonly employed mechanism utilized by transcription factors to activate gene expression. conversely, histone deacetylation is the most common mechanism used to inactivate genes. histone deacetylase inhibitors (hdacis) are in advanced clinical development as cancer therapeutic agents [1].mi-192 is a novel benzamide-based compound that had marked selectivity for the class i enzymes, hdac2 and hdac3. in hela cell extracts, mi-192 inhibited hdac activity with ic50 value of 1.5 μm. mi-192 selectively inhibited recombinant hdac2 and hdac3 with ic50 values of 30 nm and 16 nm, respectively over hdac1, 4, 6, 7, and 8 (ic50s = 4.8, 5, >10, 4.1, and >10 μm, respectively). mi-192 showed the greatest growth inhibitory effect against the leukemic cell lines with an effective dose of 0.1-0.4 μm. mi-192 was cytotoxic and promoted apoptosis and differentiation in leukaemic cell lines [1]. in the human prostate cancer cell line pc3, mi-192 significantly increased tubulin acetylation and ablated the dynamic behaviour of microtubules in live cells [2].
Biochem/physiol Actions
MI192 is a potent and selective histone deacetylase 3 (HDAc 3) inhibitor that inhibits IL-6 production in peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) but not healthy PBMCs.
Einzelnachweise
[1]. boissinot, m.,inman, m.,hempshall, a., et al. induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor mi-192. leukemia research 36, 1304-1310 (2012).
[2]. bacon t, seiler c, wolny m, et al. histone deacetylase 3 indirectly modulates tubulin acetylation. biochem j. 2015 dec 15;472(3):367-77.

MI-192 Upstream-Materialien And Downstream Produkte

MI-192 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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