N-[1-[2-(4-Ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl]-N-phenylpropionamidhydrochlorid

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H225：Flüssigkeit und Dampf leicht entzündbar.

  H370：Schädigt die Organe.

• Sicherheit

  P210：Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P370+P378：Bei Brand: zum Löschen verwenden.

  P403+P235：An einem gut belüfteten Ort aufbewahren. Kühl halten.

ALFENTANIL HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Alfentanil is a narcotic analgesic with a more rapid onset and shorter duration of action than its structural relative fentanyl. The primary utility of alfentanil is in surgical analgesia/anesthesia, especially for cardiac compromised patients and in procedures of short duration.

• Beschreibung

  Alfentanil (hydrochloride) (Item No. 19292) is an analytical reference standard characterized as an opioid. Alfentanil is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

• Chemische Eigenschaften

  Tan Solid

• Originator

  Jansseu (Belgium)

• Verwenden

  An opioid analgesic receptor agonist for pain treatment. Tetrazole derivative of Fentanyl. Analgesic (narcotic). Controlled substance (opiate)

• Manufacturing Process

  A mixture of 22 parts of 1-ethyl-1,4-dihydro-5H-tetrazol-5-one, 45 parts of 1- bromo-2-chloroethane, 26 parts of sodium carbonate, 0.3 part of potassium iodide and 240 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with water-separator. The reaction mixture is cooled, water is added and the layers are separated. The aqueous phase is extracted three times with dichloromethane. The combined organic phases are dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using trichloromethane as eluent. The pure fractions are collected and the eluent is evaporated, yielding 28.4 parts (80%) of 1-(2-chloroethyl)-4-ethyl- 1,4-dihydro-5H-tetrazol-5-one as a residue.
  A mixture of 1.8 parts of 1-(2-chloroethyl)-4-ethyl-1,4-dihydro-5H-tetrazol-5- one, 3.45 parts of N-[4-(methoxymethyl)-4-piperidinyl]-Nphenylpropanamide, 5 parts of sodium carbonate, 0.2 part of potassium iodide and 240 parts of 4-methyl-2-pentanone is stirred and refluxed overnight with water-separator. The reaction mixture is poured onto water and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is purified by column-chromatography over silicagel using a mixture of trichloromethane and methanol (97:3 by volume) as eluent. The pure fractions are collected and the eluent is evaporated. The residue is converted into the hydrochloride salt in 2-propanone. The salt is filtered off and crystallized from 2-propanone, yielding 1.5 parts (33.3%) of N-[1-[2-(4-ethyl- 4,5-dihydro-5-oxo-1H-tetrazol-1-yl]-4-(methoxymethyl)-4-piperidinyl]-Nphenylpropanamide monohydrochloride monohydrate; melting point 140.8°C.

• Trademarks

  Alfenta (Akorn);RAPIFEN.

• Therapeutic Function

  Narcotic analgesic

ALFENTANIL HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

69049-06-5, ALFENTANIL HYDROCHLORIDE Verwandte Suche: