enniatin A1 Struktur

enniatin A1

Bezeichnung:enniatin A1

CAS-Nr4530-21-6

Englisch Name:enniatin A1

CBNumberCB32079106

SummenformelC35H61N3O9

Molgewicht667.879

MOL-Datei4530-21-6.mol

enniatin A1 physikalisch-chemischer Eigenschaften

Schmelzpunkt	116-117 °C
Siedepunkt	840.5±65.0 °C(Predicted)
Dichte	1.027±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO: soluble10mg/mL
Aggregatzustand	White to off-white crystalline solid.
pka	-1.44±0.70(Predicted)
Biologische Quelle	Gnomonia errabunda

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	23/24/25
S-Sätze:	45
RIDADR	2811
WGK Germany	3
HazardClass	6.1(a)
PackingGroup	I

Gefahreninformationscode (GHS)

enniatin A1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Enniatin A1 is a mycotoxin capable of creating negative CNS effects due to their ability to cross the blod-brain barrier. Secondary metabolite of microbes, it is associated with mold, moisture damage and asthma development.
Verwenden
Enniatins are a family of depsipeptide ionophores produced by several Fusarium species. Recently, the effects of the enniatins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin A1 is one of four major analogues of the enniatin complex .
Verwenden
Enniatins are a family of depsipeptide ionophores, produced several Fusarium species. More recently, the effects of the ennitins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumour action have received more focus. Enniatin A1 is one of four major analogues of the enniatin complex and has previously not been available for investigation.
Definition
ChEBI: An enniatin obtained from formal cyclocondensation of one N-[(2R)-2-hydroxy-3-methylbutanoyl]-N-methyl-L-valine and two N-[(2R)-2-hydroxy-3-methylbu anoyl]-N-methyl-L-isoleucine units.
Biochem/physiol Actions
Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42).

enniatin A1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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