4-Thiouridin

Bezeichnung:4-Thiouridin

CAS-Nr13957-31-8

Englisch Name:4-THIOURIDINE

CBNumberCB3202841

SummenformelC9H12N2O5S

Molgewicht260.27

MOL-Datei13957-31-8.mol

Synonyma

4-Thiouridin

4-Thiouridin physikalisch-chemischer Eigenschaften

Schmelzpunkt	139-140℃ (ethanol )
Dichte	1.72±0.1 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly, Sonicated)
Aggregatzustand	crystalline
pka	4.75±0.20(Predicted)
Farbe	light yellow
PH	8.2
Wasserlöslichkeit	Soluble in water (20 mg/ml), and methanol (10 mg/ml).
maximale Wellenlänge (λmax)	245，331 (pH 6.5)；316 (pH 12)
InChIKey	ZLOIGESWDJYCTF-XVFCMESISA-N
CAS Datenbank	13957-31-8(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	3
HS Code	29349990

Gefahreninformationscode (GHS)

4-THIOURIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
4-Thiouridine (4-SU) is a photoactivatable ribonucleoside analog that is widely used for RNA analysis, including short-range RNA-RNA crosslinking and nascent RNA labeling. The crosslinking thio moiety is attached directly to the nucleotide base, thus 4-SU differs from uridine only by a single sulfur substitution. This offers the advantage of incorporating into an RNA chain with minimal structural perturbation and with similar base-pairing properties, reducing the likelihood that substitution will impair RNA interactions or activities.
Verwenden
Nucleotide analogue, essential for cell growth in certain bacterial species. This compound is also able to chelate with certain metal ions, and in tRNA it can act as a built-in antiphotomutagenic agent that protects Escherichia coli cells against mutagenesis.
Verwenden
4-Thiouridine is a constituent of several transfer RNA's. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.
Definition
ChEBI: A thiouridine in which the oxygen replaced by sulfur is that at C-4.
Allgemeine Beschreibung
4-Thiouridine is a photoreactive uridine analog.
Biochem/physiol Actions
4-Thiouridine plays a role in assessing nascent RNA synthesis. It also enhances site-specific crosslinking. 4-Thiouridine also acts as a photoaffinity probe due to its stability even while lacking specific photoactivation. It can also be incorporated into RNAs.
Lager
Store at -20°C

4-Thiouridin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

13957-31-8, 4-THIOURIDINE Verwandte Suche:

Send Inquriy