Butopamine

Butopamine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Butopamine,ZYF Pharm Chemical

• Definition

  ChEBI: A 4-(1-hydroxy-2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)phenol in which both stereocentres have R configuration. It is the most active of the four diastereoisomers that make up the animal feed additive ractopamine.

• Manufacturing Process

  A solution of 32.8 g (0.2 m) of methyl 2-(4-hydroxyphenyl)ethyl ketone and 42.6 g (0.2 m) of 1-(4-hydroxyphenyl)-2-aminoethanol in 380 ml of ethanol containing 3.8 g of 5% palladium on carbon was stirred for 16 h at 60°C under hydrogen at 55 psi. The reaction mixture was then filtered, and the filtrate was diluted by addition of 350 ml of water. The aqueous mixture was concentrated to a volume of about 400 ml, and then washed with dichloromethane.
  The aqueous mixture was acidified by addition of 50 ml of conc. hydrochloric acid. After standing at room temperature for 2 h, the aqueous acid mixture was filtered and the filter cake was washed with 40 ml of ice water and dried at 50°C in vacuum to provide 47.0 g of 1-(4-hydroxyphenyl-2- propylamino]ethanol hydrochloride, melting point 124-129°C.
  The 1-(4-hydroxyphenyl)-2-[1-methyl-3-(4-hydroxyphenyl)propylamino] ethanol was obtained by treatment of 1-(4-hydroxyphenyl-2- propylamino]ethanol hydrochloride with sodium hydroxide.

• Therapeutic Function

  Cardiotonic

Butopamine Upstream-Materialien And Downstream Produkte

Butopamine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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