Marimastat

Bezeichnung:Marimastat

CAS-Nr154039-60-8

Englisch Name:Marimastat

CBNumberCB31073538

SummenformelC15H29N3O5

Molgewicht331.41

MOL-Datei154039-60-8.mol

Marimastat physikalisch-chemischer Eigenschaften

Schmelzpunkt	148℃
Dichte	1.140±0.06 g/cm3(Predicted)
RTECS-Nr.	EJ6665000
storage temp.	-20°C
Löslichkeit	DMSO: ≥20mg/mL
Aggregatzustand	White solid
pka	9.44±0.40(Predicted)
Farbe	White to gray

Sicherheit

WGK Germany	3
HS Code	29241990

Gefahreninformationscode (GHS)

Marimastat Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Marimastat acts as a matrix metalloproteinase inhibitor in the treatment of various cancers, and pathological occurrences such as arthritis and atherosclerosis.
Verwenden
Marimastat has been used as an inhibitor of:
- metalloproteinase 2/9 (MMP2/9), to study its effects on exercise-mediated interleukin-6 (IL-6) release in mice
- metalloproteinase, to determine protease activity in Pseudomonas aeruginosa cultures
- metalloproteinase 10 (MMP10), to study its effect on monoclonal antibody H3 binding to MMP10
Verwenden
Antineoplastic (matrix metalloproteinase inhibitor).
Definition
ChEBI: Marimastat is a secondary carboxamide resulting from the foraml condensation of the carboxy group of (2R)-2-[(1S)-1-hydroxy-2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoic acid with the alpha-amino group of N,3-dimethyl-L-valinamide. It has a role as an antineoplastic agent and a matrix metalloproteinase inhibitor. It is a secondary carboxamide and a hydroxamic acid.
Allgemeine Beschreibung
An orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC₅₀ in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn²⁺. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo.
Biologische Aktivität
Broad spectrum inhibitor of matrix metalloprotease (MMP) (IC 50 values are 3, 5, 6, 9 and 13 nM for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 respectively). In vivo inhibits peritoneal dissemination of human gastric cancer cells through inhibition of tumor angiogenesis.
Biochem/physiol Actions
Marimastat is a broad spectrum matrix metalloprotease (MMP) inhibitor
Lager
Store at -20°C

Marimastat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

154039-60-8, Marimastat Verwandte Suche:

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