VILAZODONE Struktur

VILAZODONE

Bezeichnung:VILAZODONE

CAS-Nr163521-12-8

Englisch Name:VILAZODONE

CBNumberCB31011682

SummenformelC26H27N5O2

Molgewicht441.52

MOL-Datei163521-12-8.mol

VILAZODONE physikalisch-chemischer Eigenschaften

Schmelzpunkt	203-205°C
Siedepunkt	745.1±60.0 °C(Predicted)
Dichte	1.34±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
Löslichkeit	DMSO (Slightly)), Methanol (Slightly)
pka	15.98±0.30(Predicted)
Aggregatzustand	Solid
Farbe	Pale Yellow to Beige
Stabilität	Very Hygroscopic
CAS Datenbank	163521-12-8

Sicherheit

Giftige Stoffe Daten

163521-12-8(Hazardous Substances Data)

VILAZODONE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
In January 2011, the U.S. FDA approved vilazodone for the treatment of major depressive disorder (MDD). Vilazodone is a novel antidepressant agent that combines potent serotonin reuptake inhibition (IC₅₀=0.2 nM) with high affinity for 5-HT1A receptors (IC₅₀=0.5 nM)and partial 5-HT1A receptor agonist functional activity. Vilazodone has good selectivity over other monoamine receptors and is efficacious in preclinical models of depression in rats and mice. Vilazodone is an indolylbutylpiperazine derivative that has been prepared by coupling of an indolylbutyl chloride or tosylate with 5-(piperazin-1-yl)benzofuran-2- carboxamide or the corresponding ester. The cyanoindole portion of vilazodone is important for conferring high affinity for both the serotonin transporter and the 5-HT1A receptor. Para-substitution on the phenyl group attached to the piperidine moiety reduces affinity for dopamine receptors, while the carboxamide group provides improved pharmacokinetic properties.
Chemische Eigenschaften
Light Yellow Solid
Originator
Merck KGaA (Germany)
Verwenden
Labelled analogue of Vilazodone
Verwenden
It is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
Verwenden
An inhibitor of ST and activator of SR-1A
Definition
ChEBI: A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder.
Trademarks
Viibryd

VILAZODONE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

163521-12-8, VILAZODONE Verwandte Suche:

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