Penbutolol

Penbutolol Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Betapressin, Hoechst , W. Germany ,1980

• Verwenden

  Anti-adrenergic (β-receptor).

• Definition

  ChEBI: Penbutolol is a member of ethanolamines.

• Manufacturing Process

  21.8 g (0.1 mol) of 1,2-epoxy-3-(2'-cyclopentylphenoxy)propane, boiling at 113°C to 115°C/0.2 mm Hg (prepared from 2-cyclopentylphenol and epichlorhydrin in the presence of alkali) were dissolved in 250 ml of ethanol; to this solution, there were added dropwise, while stirring.8.9 g (0.15 mol) of t-butylamine. The reaction mixture was stirred for 2 hours at 60°C and then the solvent and the excess t-butylamine were removed by distillation. The residue which had been purified via the aqueous hydrochloride, crystallized, after removal of the ether by evaporation, upon rubbing or inoculation and yielded, after recrystallization from n-heptane, the 1-t-butylamino-2-hydroxy3-(2'-cyclopentylphenoxy)propane which was found to melt at 69°C to 70°C.

• Trademarks

  Levatol(Schwarz Pharma).

• Therapeutic Function

  Beta-adrenergic blocker

• Sicherheitsprofil

  Poison by ingestion and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Penbutolol Upstream-Materialien And Downstream Produkte

Penbutolol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(14)Suppliers

38363-40-5, Penbutolol Verwandte Suche: