Desonid

Bezeichnung:Desonid

Englisch Name:Desonide

CBNumberCB2783466

SummenformelC24H32O6

Molgewicht416.51

Synonyma

Desonid

Desonid physikalisch-chemischer Eigenschaften

Schmelzpunkt	272-274?C
Siedepunkt	580.1±50.0 °C(Predicted)
Dichte	1.30±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	DMF (Slightly, Sonicated), DMSO (Sparingly), Methanol (Slightly, Heated)
Aggregatzustand	Solid
pka	12.87±0.10(Predicted)
Farbe	White to Off-White
CAS Datenbank	638-94-8(CAS DataBase Reference)

Sicherheit

HS Code	2937290000
Toxizität	LD50 in rats (mg/kg): 93 s.c. (Phillips)

Gefahreninformationscode (GHS)

Chemische Eigenschaften
Off-White Solid
Originator
Tridesilon,Dome,US,1972
Verwenden
antifungal
Verwenden
Desonide(Budesonide EP Impurity F) is an impurity of Budesonide (B689490), an anti-inflammatory.
Verwenden
Anti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490).
Indications
Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid.
Definition
ChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.
Manufacturing Process
Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4- Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4- pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction mixture is diluted with water (50 ml) and extracted with chloroform (3x25 ml), the combined extracts then being washed with water (30 ml) and dried over anhydrous sodium sulfate. The residue obtained by removal of solvent crystallized from ethyl acetate-petroleum ether as small plates (25 mg), melting point 257°-260°C.
Trademarks
Desowen (Galderma); Tridesilon (Perrigo).
Therapeutic Function
Antiinflammatory