1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Struktur

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

Bezeichnung:1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CAS-Nr4004-05-1

Englisch Name:1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

CBNumberCB2477530

SummenformelC41H78NO8P

Molgewicht744.05

MOL-Datei4004-05-1.mol

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine physikalisch-chemischer Eigenschaften

Schmelzpunkt	200°C(lit.)
Siedepunkt	759.2±70.0 °C(Predicted)
Dichte	1.008±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO: 31.25 mg/mL (42.00 mM)
Aggregatzustand	lyophilized powder
pka	1.17±0.50(Predicted)
Farbe	White to Light yellow
BRN	1718431
InChIKey	MWRBNPKJOOWZPW-XFBMKQTANA-N
SMILES	[C@H](COP(O)(=O)OCCN)(COC(=O)CCCCCCC/C=C\CCCCCCCC)OC(=O)CCCCCCC/C=C\CCCCCCCC \|&1:0,r\|

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-38-40-48/20/22-67-36/38-20-63
S-Sätze:	36/37-26
RIDADR	UN 1888 6.1/PG 3
WGK Germany	3
F	8-10-23
HS Code	29232000

Gefahreninformationscode (GHS)

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R38:Reizt die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R48/20/22:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Einatmen und durch Verschlucken.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Beschreibung
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a neutral phospholipid and displays sensitivity towards pH change and has been used in the preparation of liposome and giant unilamellar vesicles (GUVs).
Phosphatidylethanolamine (PE) is formed primarily in the reaction of CDP-ethanolamine and diacylglycerol. PE is one of the major components of cell membranes in bacteria and in nervous system.
Chemische Eigenschaften
Yellowish wax
Verwenden
18:1 (Δ9-Cis) PE (DOPE) has been used in the preparation of liposome for human uncoupling protein 1 (UCP1) reconstitution and for Caenorhabditis elegans autophagy related cysteine protease protein conjugation studies. It has also been used for the generation of giant unilamellar vesicles (GUVs) for septin induced deformation studies.
Verwenden
1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
Verwenden
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) forms heterogenous liposomes with N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methylsulfate (DOTAP), which are used as delivery vehicles for therapeutic agents.
Definition
ChEBI: Dioleoyl phosphatidylethanolamine is a phosphatidylethanolamine in which the phosphatidyl acyl groups are both oleoyl.
Allgemeine Beschreibung
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (18:1 (Δ9-Cis) PE (DOPE)) is a neutral phospholipid and displays sensitivity towards pH change. At acidic it is an inverted hexagonal micelle and transforms to spherical micelle at alkaline pH.
Biologische Aktivität
DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).
Biochem/physiol Actions
DOPE in mixed membranes have been found to decrease fluorescence lifetime and increase acyl-chain order. DOPE is an essential component of cationic liposomes designed to deliver DNA into gliosarcoma and kidney cell lines (gene therapy).
Lager
Store at -20°C

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Upstream-Materialien And Downstream Produkte

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4004-05-1, 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine Verwandte Suche:

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