Phen-DC3 Trifluoromethanesulfonate

Phen-DC3 Trifluoromethanesulfonate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  Phen-DC3 Trifluoromethanesulfonate is a G4-specific ligand that inhibits the helicases FANCJ and DinG with IC50s of 65±6 and 50±10 nM, respectively.

• in vitro

  In WT cells, a CEB1-WT array is rather stable but undergoes frequent rearrangements upon addition of 10 μM Phen-DC3 Trifluoromethanesulfonate (Phen-DC3). It is found that the c-Myc allele exhibits significant destabilization upon Phen-DC3 Trifluoromethanesulfonate treatment and PIF1 deletion. The CEB25-L111(T) array is stable in WT cells, it becomes unstable upon addition of Phen-DC3 Trifluoromethanesulfonate or deletion of PIF1. It is also highly destabilized in the presence of Phen-DC3 Trifluoromethanesulfonate or in the absence of PIF1. The CEB1-loop CEB25 allele remains fully stable in both PIF1-treated and WT cells.

• target

  IC50: 65±6 nM (G4 substrate, FANCJ helicase), 50±10 nM (G4 substrate, DinG helicases)

Phen-DC3 Trifluoromethanesulfonate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(16)Suppliers