Verbascoside

Bezeichnung:Verbascoside

CAS-Nr61276-17-3

Englisch Name:Verbascoside

CBNumberCB2306760

SummenformelC29H36O15

Molgewicht624.59

MOL-Datei61276-17-3.mol

Verbascoside physikalisch-chemischer Eigenschaften

Schmelzpunkt	232℃
Siedepunkt	908.8±65.0 °C(Predicted)
Dichte	1.60±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO (Slightly), Ethyl Acetate (Very Slightly), Methanol (Slightly)
pka	9.31±0.10(Predicted)
Aggregatzustand	Solid
Farbe	White to Pale Yellow
Stabilität	Hygroscopic
InChIKey	FBSKJMQYURKNSU-ZLSOWSIRSA-N
LogP	0.077 (est)
CAS Datenbank	61276-17-3(CAS DataBase Reference)

Sicherheit

S-Sätze:	24/25
WGK Germany	2
RTECS-Nr.	LZ5786000
HS Code	29389090
Toxizität	LD50 oral in rat: > 5gm/kg

Gefahreninformationscode (GHS)

Verbascoside Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White solid
Verwenden
Verbascoside is an agent producing effects on anti-GBM nephritis in rats. Effective agent against glomerulonephritis. Phenolic anti-oxidant agent.
Definition
ChEBI: Acteoside is a glycoside that is the alpha-L-rhamnosyl-(1->3)-beta-D-glucoside of hydroxytyrosol in which the hydroxy group at position 4 of the glucopyranosyl moiety has undergone esterification by formal condensation with trans-caffeic acid. It has a role as a neuroprotective agent, an antileishmanial agent, an anti-inflammatory agent, a plant metabolite and an antibacterial agent. It is a cinnamate ester, a disaccharide derivative, a member of catechols, a polyphenol and a glycoside. It is functionally related to a hydroxytyrosol and a trans-caffeic acid.
Enzyminhibitor
This plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.

Verbascoside Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

61276-17-3, Verbascoside Verwandte Suche:

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