Desflurane

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Desflurane Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSE FLüSSIGKEIT.

• PHYSIKALISCHE GEFAHREN

  Die Dämpfe sind schwerer als Luft. Sie können sich in tiefer gelegenen Bereichen sammeln und den Luftsauerstoff verdrängen.

• CHEMISCHE GEFAHREN

  Bei Kontakt mit heißen Gegenständen oder Flammen Zersetzung unter Bildung ätzender Gase wie Fluorwasserstoff.

• ARBEITSPLATZGRENZWERTE

  TLV nicht festgelegt (ACGIH 2005).
  MAK nicht festgelegt (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation der Dämpfe und durch Verschlucken.

• INHALATIONSGEFAHREN

  Beim Verdampfen bei 20°C kann sehr schnell eine gesundheitsschädliche Kontamination der Luft eintreten.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Flüssigkeit reizt die Augen und die Haut. Der Dampf reizt die Atemwege. Möglich sind Auswirkungen auf Zentralnervensystem und Herz-Kreislaufsystem. Exposition gegenüber hohen Konzentrationen kann zu Bewusstlosigkeit führen.

• LECKAGE

  Belüftung. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. Persönliche Schutzausrüstung: Umgebungsluftunabhängiges Atemschutzgerät.

• S-Sätze Betriebsanweisung:

  S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).

• Beschreibung

  Desflurane is a new inhalation anesthetic introduced for induction and maintenance of general anesthesia in adults. Due to reports of respiratory irritation, desflurane may be used only for maintenance in children. Although almost structurally identical to isoflurane, a halogen replacement gives desflurane an improved pharmacokinetic profile. It is less soluble in blood and tissue and produces a fast onset of action and a more rapid recovery from anesthesia.

• Chemische Eigenschaften

  Desflurane is a clear, colourless, mobile, heavy liquid. It is similar to isoflurane (CHF2-O-CHCl-CF3) in that both are halogenated compounds of methyl ethane, except that chlorine is replaced with fluorine in the α-ethyl portion. The halogenation of fluorine reduces the solubility of blood and tissues and alters the boiling point, vapor pressure and stability of desflurane, enhancing its molecular stability as well as its resistance to biodegradation and alkaline degradation.
  

• Originator

  Anaquest (BOC Healthcare) (U.S.A.)

• History

  Desflurane was first synthesized by Russel et al U.S. at the 29. of July 1975. The synthesis was started by using floural methyl hemiacetal (CF3CH(OH)OCH3) and converting it to 1,2,2,2- tetraflouroethyl methyl ether (CF3CHFOCH3). Next step was chlorinating two hydrogen atoms of the methyl-group to CF3CHFOCHCl2. This next to last molecule was charged with HF in the presence of antimony pentachloride (SBCL5) to Desflurane. But this way of synthesizing Desfluran was not usable for industrial synthesis, because of the less yield of Desflurane and the expensive educts.

• Verwenden

  Anesthetic.

• synthetische

  Isoflurane and bromine trifluoride were reacted overnight at room temperature to synthesize desflurane in 62% yield.

• Definition

  ChEBI: Desflurane is an organofluorine compound. It has a role as an inhalation anaesthetic. It is functionally related to a methoxyethane.

• Trademarks

  Suprane (Baxter Healthcare).

• Biologische Funktion

  Desflurane (Suprane) shares most of the pharmacological properties of isoflurane. Desflurane has low tissue and blood solubility compared with other halogenated hydrocarbons, and its anesthetic partial pressure is thus established more rapidly. Recovery is similarly prompt when the patient is switched to room air or oxygen. Desflurane’s popularity for outpatient procedures stems from its rapid onset and prompt elimination from the body by exhalation. A disadvantage is that desflurane irritates the respiratory tract; thus, it is not preferred for induction of anesthesia using an inhalational technique. However, desflurane may be used to maintain anesthesia after induction with an alternative IV or inhalational agent, preserving the advantage of rapid recovery.
  Desflurane, like other halogenated hydrocarbon anesthetics, causes a decrease in blood pressure.The reduced pressure occurs primarily as a consequence of decreased vascular resistance, and since cardiac output is well maintained, tissue perfusion is preserved.
  Desflurane stimulates the sympathetic nervous system and causes abrupt transient tachycardia during induction or as the concentration of the agent is raised to meet the patient’s changing needs.
  Desflurane causes an increase in the rate of ventilation, a decrease in tidal volume, and a decrease in minute volume as inspired concentrations only slightly exceed 1 MAC. Thus should anesthesiologists require desflurane to be administered near or above MAC levels, patients are likely to have marked reductions in PCO2.

• Allgemeine Beschreibung

  Desflurane is a nonflammable, colorless, very volatile liquidpackaged in amber-colored vials. The boiling point is22.8°C, and it requires a vaporizer specifically designed fordesflurane. The manufacturer states that the vials can bestored at room temperature. Desflurane has a blood:gas partitioncoefficient of 0.42, an MAC of 7.3% and an oil:gaspartition coefficient of 18.7. The low blood:gas partition coefficientleads to fast induction times and short recoverytimes. Desflurane is not recommended for induction anesthesiain children because of the high incidence of laryngospasms(50%), coughing (72%), breath holding (68%),and increase in secretions (21%). Desflurane can producea dose-dependent decrease in blood pressure and concentrationsexceeding 1 MAC may cause transient increases inheart rate. Desflurane can react with desiccated carbon dioxideabsorbents to produce carbon monoxide that may resultin elevated levels of carboxyhemoglobin.24.

• Stoffwechsel

  Desflurane is not metabolized to any great extent and, therefore, has not been associated with hepatotoxicity or nephrotoxicity. Metabolites, mostly trifluoroacetate, account for less than 0.02% of the administered dose. Whereas desflurane can react with soda lime or Baralyme to form carbon monoxide, no reports of adverse outcomes in patients have appeared.

Desflurane Upstream-Materialien And Downstream Produkte

Desflurane Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(53)Suppliers

57041-67-5, Desflurane Verwandte Suche: