OCHRATOXIN B

Bezeichnung:OCHRATOXIN B

CAS-Nr4825-86-9

Englisch Name:OCHRATOXIN B

CBNumberCB2297543

SummenformelC20H19NO6

Molgewicht369.37

MOL-Datei4825-86-9.mol

OCHRATOXIN B physikalisch-chemischer Eigenschaften

Schmelzpunkt	221° (van der Merwe)
alpha	D -35° (c = 0.15 in ethanol)
Siedepunkt	632.4±55.0 °C(Predicted)
Dichte	1.361±0.06 g/cm3(Predicted)
Flammpunkt	-11 °C
storage temp.	2-8°C
Löslichkeit	DMF: 10 mg/ml; DMSO: 15 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.50 mg/ml
Aggregatzustand	A crystalline solid
pka	3.40±0.10(Predicted)
Farbe	White to off-white
EPA chemische Informationen	L-Phenylalanine, N-[[(3R)-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]- (4825-86-9)

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F
R-Sätze:	22-36/37/38-65-48/23/24/25-36/38-11-46-45-36-20/21/22
S-Sätze:	26-36-45-16-53-36/37-62
RIDADR	UN 3462 6.1/PG 3
WGK Germany	3
RTECS-Nr.	AY6825000
HazardClass	6.1(a)
PackingGroup	I
HS Code	39229000
Giftige Stoffe Daten	4825-86-9(Hazardous Substances Data)

Gefahreninformationscode (GHS)

OCHRATOXIN B Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R65:Gesundheitsschädlich: kann beim Verschlucken Lungenschäden verursachen.
R48/23/24/25:Giftig: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R36/38:Reizt die Augen und die Haut.
R11:Leichtentzündlich.
R46:Kann vererbbare Schäden verursachen.
R45:Kann Krebs erzeugen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S16:Von Zündquellen fernhalten - Nicht rauchen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
Beschreibung
Ochratoxins are mycotoxins produced by Aspergillus and Penicillium species of fungi that contaminate foods. Ochratoxin A (OTA, ) is a chlorinated form with toxicity that targets the kidneys, causing nephropathy and renal adenomas. OTB is a non-chlorinated analog of OTA that has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. OTB inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 μg/ml but lacks the genotoxic activity of OTA, even at higher concentrations.
Verwenden
Ochratoxin B is the non-chlorinated analogue of the much more extensively studied ochratoxin A. It is co-produced by the same species of Aspergillus and Penicillium that are associated with food spoilage. Ochratoxin B has received little focused investigation and its mode of action and potential hazards have been inferred from ochratoxin A.
Verwenden
Ochratoxins are toxic metabolites from Aspergillus orchraceus.
Definition
ChEBI: Ochratoxin B is a phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid. Ochratoxin B differs from the more naturally abundant ochratoxin A in the absence of the dihydroisocoumarin chlorine atom. It has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. It inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 mug/ ml but lacks the genotoxic activity of ochratoxin A, even at higher concentrations. It has a role as an Aspergillus metabolite, a Penicillium metabolite, a mycotoxin and a calcium channel blocker. It is a phenylalanine derivative, a N-acyl-L-phenylalanine, a member of isochromanes and a monocarboxylic acid. It is a conjugate acid of an ochratoxin B(1-).
Allgemeine Beschreibung
Crystals that exhibit blue fluorescence.
Reaktivität anzeigen
OCHRATOXIN B is incompatible with strong oxidizing agents, strong acids and strong bases. OCHRATOXIN B is a carboxylic acid derivative. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt.
Brandgefahr
Flash point data for OCHRATOXIN B are not available. OCHRATOXIN B is probably combustible.

OCHRATOXIN B Upstream-Materialien And Downstream Produkte

OCHRATOXIN B Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

4825-86-9, OCHRATOXIN B Verwandte Suche:

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