OMadacycline (tosylate) Struktur

OMadacycline (tosylate)

Bezeichnung:OMadacycline (tosylate)

CAS-Nr1075240-43-5

Englisch Name:OMadacycline (tosylate)

CBNumberCB22685931

SummenformelC36H48N4O10S

Molgewicht728.86

MOL-Datei1075240-43-5.mol

OMadacycline (tosylate) physikalisch-chemischer Eigenschaften

storage temp.	4°C, protect from light
Löslichkeit	Soluble in DMSO
Aggregatzustand	Solid
Farbe	White to yellow
InChIKey	SETFNHZTVGTBHC-MPRIKUDSNA-N
SMILES	S(C1C=CC(C)=CC=1)(O)(=O)=O.O[C@@]12C(C(C(=O)N)=C(O)[C@@H](N(C)C)[C@]1([H])C[C@]1([H])CC3=C(C=C(CNCC(C)(C)C)C(O)=C3C(=O)C1=C2O)N(C)C)=O \|&1:12,20,24,27,r\|

OMadacycline (tosylate) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Omadacycline tosylate is a semisynthetic tetracycline-class antibacterial agent, which has been designated by some as a “new-generation tetracycline” or “the first in a new class of aminomethylcyclines.” Omadacycline has been structurally modified to provide effectiveness against certain strains of bacteria that have mechanisms to resist the action of older tetracyclines. The new agent binds to the 30S ribosomal unit, blocks bacterial protein synthesis, and is generally bacteriostatic^[1]. Omadacycline tosylate has broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline tosylate has been studied in acute bacterial skin and skin structure infections, community-acquired pneumonia and urinary tract infections.
Verwenden
OMadacycline (tosylate) is a new type of 9-aminomethylcycline drug, which is a semi-synthetic compound obtained by modifying chemical groups on the basis of minocycline. The modification can help omacycline overcome bacterial resistance. Pharmacological properties, expand the antibacterial spectrum, and improve the pharmacokinetic properties.
Biologische Aktivität
OMadacycline (tosylate) is an aminecycline antibiotic with antibacterial activity against Gram-positive and negative aerobic bacteria and some anaerobic bacteria.
Mode of action
(1) OMadacycline (tosylate) specifically binds to the A site of the 30S subunit of the bacterial ribosome, inhibits the normal binding of aminoacyl-tRNA to this site, terminates the elongation of the peptide chain, and blocks the synthesis of proteins to produce a bacteriostatic effect.
(2) The electron-donating group (dimethylamino) of the modified group of it can improve the activity and help to overcome the bacterial efflux pump resistance mechanism.
(3) The aminomethyl modification of it can make it overcome the bacterial ribosome protection mechanism (caused by the ribosome protection protein gene TetO) and enhance oral bioavailability.
(4) But it cannot resist the effect of Tet(X) modification enzyme.
Einzelnachweise
[1] DANIEL A. HUSSAR; Elias B C. Omadacycline tosylate, Sarecycline hydrochloride, Rifamycin sodium, and Moxidectin[J]. Journal of the American Pharmacists Association, 2019. DOI:10.1016/j.japh.2019.07.016.

OMadacycline (tosylate) Upstream-Materialien And Downstream Produkte

OMadacycline (tosylate) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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